Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy
Reductions in right prefrontal cerebral blood flow have been correlated with symptomatic improvement in depressed individuals receiving electroconvulsive therapy (ECT). Non-invasive near infrared spectroscopy has previously been shown to reliably measure changes in cerebral hemoglobin concentrations...
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description | Reductions in right prefrontal cerebral blood flow have been correlated with symptomatic improvement in depressed individuals receiving electroconvulsive therapy (ECT). Non-invasive near infrared spectroscopy has previously been shown to reliably measure changes in cerebral hemoglobin concentrations and oxygen saturation. In this study, we measured the concentration and oxygen saturation of hemoglobin on the right and left frontal brain regions of nine patients during right unilateral ECT. In all patients, we have found that the electrically induced seizure causes a stronger cerebral deoxygenation on the side ipsilateral to the electrical current (−21±5%) with respect to the contralateral side (−6±4%). On the brain side ipsilateral to the ECT electrical discharge, we have consistently observed a discharge-induced decrease in the total hemoglobin concentration, i.e. in the cerebral blood volume, by −7±3 μM, as opposed to an average increase by 6±3 μM on the contralateral side. The ipsilateral decrease in blood volume is assigned to a vascular constriction associated with the electrical discharge, as indicated by the observed decrease in cerebral oxy-hemoglobin concentration and minimal change in deoxy-hemoglobin concentration during the electrical discharge on the side of the discharge. These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT. |
doi_str_mv | 10.1016/j.brainres.2003.08.034 |
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Non-invasive near infrared spectroscopy has previously been shown to reliably measure changes in cerebral hemoglobin concentrations and oxygen saturation. In this study, we measured the concentration and oxygen saturation of hemoglobin on the right and left frontal brain regions of nine patients during right unilateral ECT. In all patients, we have found that the electrically induced seizure causes a stronger cerebral deoxygenation on the side ipsilateral to the electrical current (−21±5%) with respect to the contralateral side (−6±4%). On the brain side ipsilateral to the ECT electrical discharge, we have consistently observed a discharge-induced decrease in the total hemoglobin concentration, i.e. in the cerebral blood volume, by −7±3 μM, as opposed to an average increase by 6±3 μM on the contralateral side. The ipsilateral decrease in blood volume is assigned to a vascular constriction associated with the electrical discharge, as indicated by the observed decrease in cerebral oxy-hemoglobin concentration and minimal change in deoxy-hemoglobin concentration during the electrical discharge on the side of the discharge. These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2003.08.034</identifier><identifier>PMID: 14625058</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Cerebral hemodynamics ; Cerebrovascular Circulation - physiology ; Depressive Disorder - blood ; Depressive Disorder - physiopathology ; Depressive Disorder - therapy ; Down-Regulation - physiology ; Electro-convulsive therapy ; Electroconvulsive therapy ; Electroconvulsive Therapy - methods ; Electroencephalography ; Female ; Functional Laterality - physiology ; Humans ; Male ; Medical sciences ; Middle Aged ; Monitoring, Physiologic - methods ; Near-infrared spectroscopy ; Oxygen Consumption - physiology ; Oxyhemoglobins - metabolism ; Predictive Value of Tests ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - physiopathology ; Psychology. 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Non-invasive near infrared spectroscopy has previously been shown to reliably measure changes in cerebral hemoglobin concentrations and oxygen saturation. In this study, we measured the concentration and oxygen saturation of hemoglobin on the right and left frontal brain regions of nine patients during right unilateral ECT. In all patients, we have found that the electrically induced seizure causes a stronger cerebral deoxygenation on the side ipsilateral to the electrical current (−21±5%) with respect to the contralateral side (−6±4%). On the brain side ipsilateral to the ECT electrical discharge, we have consistently observed a discharge-induced decrease in the total hemoglobin concentration, i.e. in the cerebral blood volume, by −7±3 μM, as opposed to an average increase by 6±3 μM on the contralateral side. The ipsilateral decrease in blood volume is assigned to a vascular constriction associated with the electrical discharge, as indicated by the observed decrease in cerebral oxy-hemoglobin concentration and minimal change in deoxy-hemoglobin concentration during the electrical discharge on the side of the discharge. These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebral hemodynamics</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive Disorder - therapy</subject><subject>Down-Regulation - physiology</subject><subject>Electro-convulsive therapy</subject><subject>Electroconvulsive therapy</subject><subject>Electroconvulsive Therapy - methods</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Near-infrared spectroscopy</subject><subject>Oxygen Consumption - physiology</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Predictive Value of Tests</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Seizure</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Treatment Outcome</subject><subject>Treatments</subject><subject>Vasoconstriction - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURS0EokPhF6psYJdgO4lj74AKClIlNrC2XuyXGY8Se7CTEfMl_C6eTqDLrixb591rvUPIDaMVo0y831d9BOcjpopTWldUVrRunpENkx0vBW_oc7KhlIpSKlVfkVcp7fO1rhV9Sa5YI3hLW7khfz65EWaMMBYeIZbODxEi2mIK3s0hOr8twlDMOywMRuzPoAneoJ8jzC74Arwtwu_TFn2ZYF7W1zyzwylsx9A7X9jlISi67W4uFv-_Ekc0cwxlTjwuY3JHPDdFOJxekxcDjAnfrOc1-fnl84_br-X997tvtx_vS9MoNpecSlBIuQIhjbTN0Ku2rmXfQCMHbpSRjQHaSWqtwha5hcHkpbBBDQpo29bX5N0l9xDDrwXTrCeXDI4jeAxL0h2rpRBt9yTIFM8ihMiguIAmhpQiDvoQ3QTxpBnVZ3d6r_-502d3mkqd3eXBm7Vh6Se0j2OrrAy8XQFIBsYsyhuXHrmWd7JtVOY-XDjMizs6jDoZh9mZdTHvW9vgnvrLX5FVwAg</recordid><startdate>20031205</startdate><enddate>20031205</enddate><creator>Fabbri, Francesco</creator><creator>Henry, Michael E.</creator><creator>Renshaw, Perry F.</creator><creator>Nadgir, Shalini</creator><creator>Ehrenberg, Bruce L.</creator><creator>Franceschini, Maria Angela</creator><creator>Fantini, Sergio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20031205</creationdate><title>Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy</title><author>Fabbri, Francesco ; Henry, Michael E. ; Renshaw, Perry F. ; Nadgir, Shalini ; Ehrenberg, Bruce L. ; Franceschini, Maria Angela ; Fantini, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-208a9e029a68c8d4fb95338b4a48f2c9c84ca0780dd9e5e2dafc0061f9f9a0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebral hemodynamics</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive Disorder - therapy</topic><topic>Down-Regulation - physiology</topic><topic>Electro-convulsive therapy</topic><topic>Electroconvulsive therapy</topic><topic>Electroconvulsive Therapy - methods</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic - methods</topic><topic>Near-infrared spectroscopy</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Predictive Value of Tests</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Seizure</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Treatment Outcome</topic><topic>Treatments</topic><topic>Vasoconstriction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fabbri, Francesco</creatorcontrib><creatorcontrib>Henry, Michael E.</creatorcontrib><creatorcontrib>Renshaw, Perry F.</creatorcontrib><creatorcontrib>Nadgir, Shalini</creatorcontrib><creatorcontrib>Ehrenberg, Bruce L.</creatorcontrib><creatorcontrib>Franceschini, Maria Angela</creatorcontrib><creatorcontrib>Fantini, Sergio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fabbri, Francesco</au><au>Henry, Michael E.</au><au>Renshaw, Perry F.</au><au>Nadgir, Shalini</au><au>Ehrenberg, Bruce L.</au><au>Franceschini, Maria Angela</au><au>Fantini, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2003-12-05</date><risdate>2003</risdate><volume>992</volume><issue>2</issue><spage>193</spage><epage>204</epage><pages>193-204</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Reductions in right prefrontal cerebral blood flow have been correlated with symptomatic improvement in depressed individuals receiving electroconvulsive therapy (ECT). Non-invasive near infrared spectroscopy has previously been shown to reliably measure changes in cerebral hemoglobin concentrations and oxygen saturation. In this study, we measured the concentration and oxygen saturation of hemoglobin on the right and left frontal brain regions of nine patients during right unilateral ECT. In all patients, we have found that the electrically induced seizure causes a stronger cerebral deoxygenation on the side ipsilateral to the electrical current (−21±5%) with respect to the contralateral side (−6±4%). On the brain side ipsilateral to the ECT electrical discharge, we have consistently observed a discharge-induced decrease in the total hemoglobin concentration, i.e. in the cerebral blood volume, by −7±3 μM, as opposed to an average increase by 6±3 μM on the contralateral side. The ipsilateral decrease in blood volume is assigned to a vascular constriction associated with the electrical discharge, as indicated by the observed decrease in cerebral oxy-hemoglobin concentration and minimal change in deoxy-hemoglobin concentration during the electrical discharge on the side of the discharge. These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>14625058</pmid><doi>10.1016/j.brainres.2003.08.034</doi><tpages>12</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Cerebral hemodynamics Cerebrovascular Circulation - physiology Depressive Disorder - blood Depressive Disorder - physiopathology Depressive Disorder - therapy Down-Regulation - physiology Electro-convulsive therapy Electroconvulsive therapy Electroconvulsive Therapy - methods Electroencephalography Female Functional Laterality - physiology Humans Male Medical sciences Middle Aged Monitoring, Physiologic - methods Near-infrared spectroscopy Oxygen Consumption - physiology Oxyhemoglobins - metabolism Predictive Value of Tests Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Seizure Spectroscopy, Near-Infrared - methods Treatment Outcome Treatments Vasoconstriction - physiology |
title | Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy |
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