Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

Pharmacogenomics offers the potential to define metabolic pathways and to provide increased knowledge of drug actions. We studied relative levels of gene expression in the rat using a microarray with 8448 rat UniGenes (1928 known genes, 6520 unknown ESTs) in the liver and kidney as a function of tim...

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Veröffentlicht in:	Pharmacogenetics (London) 2002, Vol.12 (1), p.55-65
Hauptverfasser:	KITA, Yasuhiro, SHIOZAWA, Masahide, WEIHONG JIN, MAJEWSKI, Rebecca R, BESHARSE, Joseph C, GREENE, Andrew S, JACOB, Howard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological and medical sciences Cholesterol - genetics Cholesterol - metabolism Circadian Rhythm - physiology CLOCK Proteins DNA Primers - chemistry Eating Food Gene Expression - physiology General pharmacology Kidney - physiology Liver - physiology Male Medical sciences Oligonucleotide Array Sequence Analysis Organ Specificity Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymerase Chain Reaction Rats Trans-Activators - genetics Trans-Activators - metabolism
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