Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress
We used the differential display-polymerase chain reaction (DD-PCR) protocol to identify genes related to antidepressant effects. Rats were subjected to different kinds of stress for 20 days, and then the antidepressants desipramine and fluoxetine were administered (10 mg/kg per day, i.p.) for 20 da...
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| Veröffentlicht in: | Neuroscience letters 2003-11, Vol.351 (3), p.206-208 |
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| creator | Yang, Hong-Ju Li, Yun-Feng Zhang, Hang-Ting Zhang, Feng-Qin Zhao, Nan Gong, Zheng-Hua Luo, Zhi-Pu |
| description | We used the differential display-polymerase chain reaction (DD-PCR) protocol to identify genes related to antidepressant effects. Rats were subjected to different kinds of stress for 20 days, and then the antidepressants desipramine and fluoxetine were administered (10 mg/kg per day, i.p.) for 20 days. DD-PCR was performed and differentially expressed cDNAs were further confirmed by dot-blot hybridization. cDNA homology analysis revealed that desipramine up-regulated the expression of microtubule-associated protein 4 (MAP-4) mRNA and fluoxetine up-regulated the expression of drebrin A mRNA in the rat hippocampus compared with the chronically stressed group. This result suggests that MAP-4 and drebrin may be involved in the antidepressant like effects of desipramine and fluoxetine. |
| doi_str_mv | 10.1016/j.neulet.2003.08.006 |
| format | Article |
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Rats were subjected to different kinds of stress for 20 days, and then the antidepressants desipramine and fluoxetine were administered (10 mg/kg per day, i.p.) for 20 days. DD-PCR was performed and differentially expressed cDNAs were further confirmed by dot-blot hybridization. cDNA homology analysis revealed that desipramine up-regulated the expression of microtubule-associated protein 4 (MAP-4) mRNA and fluoxetine up-regulated the expression of drebrin A mRNA in the rat hippocampus compared with the chronically stressed group. This result suggests that MAP-4 and drebrin may be involved in the antidepressant like effects of desipramine and fluoxetine.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2003.08.006</identifier><identifier>PMID: 14623141</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antidepressive Agents - pharmacology ; Biological and medical sciences ; Chronic Disease ; Chronic stress ; Desipramine ; Differential display ; Drebrin A ; Fluoxetine ; Hippocampus - drug effects ; Hippocampus - metabolism ; Male ; Medical sciences ; Microtubule-associated protein 4 ; Microtubule-Associated Proteins - biosynthesis ; Microtubule-Associated Proteins - genetics ; Neuropeptides - biosynthesis ; Neuropeptides - genetics ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; RNA, Messenger - biosynthesis ; Stress, Physiological - genetics ; Stress, Physiological - metabolism ; Up-Regulation - drug effects ; Up-Regulation - physiology</subject><ispartof>Neuroscience letters, 2003-11, Vol.351 (3), p.206-208</ispartof><rights>2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-ad9768abc45a8b050c3440d749421521dad84a3c7b1ef17f84cfa7c8f70134ef3</citedby><cites>FETCH-LOGICAL-c419t-ad9768abc45a8b050c3440d749421521dad84a3c7b1ef17f84cfa7c8f70134ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394003009789$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15217320$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14623141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Hong-Ju</creatorcontrib><creatorcontrib>Li, Yun-Feng</creatorcontrib><creatorcontrib>Zhang, Hang-Ting</creatorcontrib><creatorcontrib>Zhang, Feng-Qin</creatorcontrib><creatorcontrib>Zhao, Nan</creatorcontrib><creatorcontrib>Gong, Zheng-Hua</creatorcontrib><creatorcontrib>Luo, Zhi-Pu</creatorcontrib><title>Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We used the differential display-polymerase chain reaction (DD-PCR) protocol to identify genes related to antidepressant effects. Rats were subjected to different kinds of stress for 20 days, and then the antidepressants desipramine and fluoxetine were administered (10 mg/kg per day, i.p.) for 20 days. DD-PCR was performed and differentially expressed cDNAs were further confirmed by dot-blot hybridization. cDNA homology analysis revealed that desipramine up-regulated the expression of microtubule-associated protein 4 (MAP-4) mRNA and fluoxetine up-regulated the expression of drebrin A mRNA in the rat hippocampus compared with the chronically stressed group. This result suggests that MAP-4 and drebrin may be involved in the antidepressant like effects of desipramine and fluoxetine.</description><subject>Animals</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Chronic stress</subject><subject>Desipramine</subject><subject>Differential display</subject><subject>Drebrin A</subject><subject>Fluoxetine</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microtubule-associated protein 4</subject><subject>Microtubule-Associated Proteins - biosynthesis</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Neuropeptides - biosynthesis</subject><subject>Neuropeptides - genetics</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Stress, Physiological - genetics</subject><subject>Stress, Physiological - metabolism</subject><subject>Up-Regulation - drug effects</subject><subject>Up-Regulation - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EokvhDRDyBW4J49hZJxekVQUFqQIJ0bPl2OPWqyQOtlPoS_DM9bIr9QYn26NvfnnmI-Q1g5oB277f1zOuI-a6AeA1dDXA9gnZsE42lexl85RsgIOoeC_gjLxIaQ8ALWvFc3LGxLbhTLAN-XO9VBFv1lFnH2YaHJ28iSGvQ8mudErBeJ3R0qUU0c9UUD1baiMOsbx2dPr-dUfx9xIxpUPCcF-A7C3-rZRrooWLOtNbvyzB6GlZE3VhHMMvP99QcxvD7A1N-cC_JM-cHhO-Op3n5PrTxx8Xn6urb5dfLnZXlRGsz5W2vdx2ejCi1d0ALRguBFgpetGwtmFW205obuTA0DHpOmGclqZzEhgX6Pg5eXfMLWP9XDFlNflkcBz1jGFNSjLeCdbK_4JMSmhlIwoojmDZXkoRnVqin3S8VwzUQZjaq6MwdRCmoFNFWGl7c8pfhwntY9PJUAHengCdjB5d1LPx6ZEr00reQOE-HDksa7vzGFUyHmeD1kc0Wdng__2TB9MnuOA</recordid><startdate>20031120</startdate><enddate>20031120</enddate><creator>Yang, Hong-Ju</creator><creator>Li, Yun-Feng</creator><creator>Zhang, Hang-Ting</creator><creator>Zhang, Feng-Qin</creator><creator>Zhao, Nan</creator><creator>Gong, Zheng-Hua</creator><creator>Luo, Zhi-Pu</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20031120</creationdate><title>Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress</title><author>Yang, Hong-Ju ; Li, Yun-Feng ; Zhang, Hang-Ting ; Zhang, Feng-Qin ; Zhao, Nan ; Gong, Zheng-Hua ; Luo, Zhi-Pu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-ad9768abc45a8b050c3440d749421521dad84a3c7b1ef17f84cfa7c8f70134ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Chronic stress</topic><topic>Desipramine</topic><topic>Differential display</topic><topic>Drebrin A</topic><topic>Fluoxetine</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microtubule-associated protein 4</topic><topic>Microtubule-Associated Proteins - biosynthesis</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Neuropeptides - biosynthesis</topic><topic>Neuropeptides - genetics</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Stress, Physiological - genetics</topic><topic>Stress, Physiological - metabolism</topic><topic>Up-Regulation - drug effects</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hong-Ju</creatorcontrib><creatorcontrib>Li, Yun-Feng</creatorcontrib><creatorcontrib>Zhang, Hang-Ting</creatorcontrib><creatorcontrib>Zhang, Feng-Qin</creatorcontrib><creatorcontrib>Zhao, Nan</creatorcontrib><creatorcontrib>Gong, Zheng-Hua</creatorcontrib><creatorcontrib>Luo, Zhi-Pu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hong-Ju</au><au>Li, Yun-Feng</au><au>Zhang, Hang-Ting</au><au>Zhang, Feng-Qin</au><au>Zhao, Nan</au><au>Gong, Zheng-Hua</au><au>Luo, Zhi-Pu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2003-11-20</date><risdate>2003</risdate><volume>351</volume><issue>3</issue><spage>206</spage><epage>208</epage><pages>206-208</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>We used the differential display-polymerase chain reaction (DD-PCR) protocol to identify genes related to antidepressant effects. Rats were subjected to different kinds of stress for 20 days, and then the antidepressants desipramine and fluoxetine were administered (10 mg/kg per day, i.p.) for 20 days. DD-PCR was performed and differentially expressed cDNAs were further confirmed by dot-blot hybridization. cDNA homology analysis revealed that desipramine up-regulated the expression of microtubule-associated protein 4 (MAP-4) mRNA and fluoxetine up-regulated the expression of drebrin A mRNA in the rat hippocampus compared with the chronically stressed group. This result suggests that MAP-4 and drebrin may be involved in the antidepressant like effects of desipramine and fluoxetine.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14623141</pmid><doi>10.1016/j.neulet.2003.08.006</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Antidepressive Agents - pharmacology Biological and medical sciences Chronic Disease Chronic stress Desipramine Differential display Drebrin A Fluoxetine Hippocampus - drug effects Hippocampus - metabolism Male Medical sciences Microtubule-associated protein 4 Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Neuropeptides - biosynthesis Neuropeptides - genetics Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar RNA, Messenger - biosynthesis Stress, Physiological - genetics Stress, Physiological - metabolism Up-Regulation - drug effects Up-Regulation - physiology |
| title | Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress |
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