Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment
A role of indices of oxidative stress, oxidative injury, and abnormal membrane phospholipid, specifically the phospholipid essential polyunsaturated fatty acids (EPUFAs) metabolism has been suggested based on studies in separate groups of patients with or without medication. The current study invest...
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Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2003-12, Vol.69 (6), p.393-399 |
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creator | Evans, D.R Parikh, V.V Khan, M.M Coussons, C Buckley, P.F Mahadik, S.P |
description | A role of indices of oxidative stress, oxidative injury, and abnormal membrane phospholipid, specifically the phospholipid essential polyunsaturated fatty acids (EPUFAs) metabolism has been suggested based on studies in separate groups of patients with or without medication. The current study investigated the relationship between these biochemical measures in first-episode psychotic patients (
N=16) at baseline and after 6 months of antipsychotic treatment (
N=5 each with risperidone and olanzapine) and compared them to matched normal subjects. The indices of oxidative stress included: antioxidant enzymes; superoxide dismutase, glutathione peroxidase and catalase; and the oxidative injury as the levels of plasma lipid peroxides. The key membrane EPUFA's been; linolenic acid, arachidonic acid, nervonic acid, docosapentaenoic acid and docosahexaenoic acid. Furthermore, the changes in these biochemical measures were correlated with clinical symptomatology. Data indicated that, at baseline, reduced levels of antioxidant enzymes were associated with increased plasma lipid peroxides and reduced membrane EPUFAs, particularly omega-3 fatty acids. Furthermore, these biochemical measures normalized after 6 months of antipsychotic treatment. Parallel-improved psychopathology indicated that membrane EPUFA status might be partly affected by oxidative damage, which together may contribute to the pathophysiology and thereby, psychopathology of schizophrenia. These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids. |
doi_str_mv | 10.1016/j.plefa.2003.08.010 |
format | Article |
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N=16) at baseline and after 6 months of antipsychotic treatment (
N=5 each with risperidone and olanzapine) and compared them to matched normal subjects. The indices of oxidative stress included: antioxidant enzymes; superoxide dismutase, glutathione peroxidase and catalase; and the oxidative injury as the levels of plasma lipid peroxides. The key membrane EPUFA's been; linolenic acid, arachidonic acid, nervonic acid, docosapentaenoic acid and docosahexaenoic acid. Furthermore, the changes in these biochemical measures were correlated with clinical symptomatology. Data indicated that, at baseline, reduced levels of antioxidant enzymes were associated with increased plasma lipid peroxides and reduced membrane EPUFAs, particularly omega-3 fatty acids. Furthermore, these biochemical measures normalized after 6 months of antipsychotic treatment. Parallel-improved psychopathology indicated that membrane EPUFA status might be partly affected by oxidative damage, which together may contribute to the pathophysiology and thereby, psychopathology of schizophrenia. These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2003.08.010</identifier><identifier>PMID: 14623492</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Alkanes - blood ; Antioxidants - therapeutic use ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Drug Therapy, Combination ; Erythrocyte Membrane - drug effects ; Erythrocyte Membrane - metabolism ; Erythrocytes - enzymology ; Essential fatty acids ; Fatty Acids, Essential - blood ; Fatty Acids, Omega-3 - therapeutic use ; Fatty Acids, Unsaturated - blood ; Humans ; Lipid Peroxides - blood ; Membrane phospholipids ; Oxidative Stress ; Psychotic Disorders - blood ; Schizophrenia</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2003-12, Vol.69 (6), p.393-399</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-52dd6d7fdd54292e6988e0b2832fa2dbb37c55670246fecb80e019a479192e073</citedby><cites>FETCH-LOGICAL-c355t-52dd6d7fdd54292e6988e0b2832fa2dbb37c55670246fecb80e019a479192e073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.plefa.2003.08.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14623492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evans, D.R</creatorcontrib><creatorcontrib>Parikh, V.V</creatorcontrib><creatorcontrib>Khan, M.M</creatorcontrib><creatorcontrib>Coussons, C</creatorcontrib><creatorcontrib>Buckley, P.F</creatorcontrib><creatorcontrib>Mahadik, S.P</creatorcontrib><title>Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>A role of indices of oxidative stress, oxidative injury, and abnormal membrane phospholipid, specifically the phospholipid essential polyunsaturated fatty acids (EPUFAs) metabolism has been suggested based on studies in separate groups of patients with or without medication. The current study investigated the relationship between these biochemical measures in first-episode psychotic patients (
N=16) at baseline and after 6 months of antipsychotic treatment (
N=5 each with risperidone and olanzapine) and compared them to matched normal subjects. The indices of oxidative stress included: antioxidant enzymes; superoxide dismutase, glutathione peroxidase and catalase; and the oxidative injury as the levels of plasma lipid peroxides. The key membrane EPUFA's been; linolenic acid, arachidonic acid, nervonic acid, docosapentaenoic acid and docosahexaenoic acid. Furthermore, the changes in these biochemical measures were correlated with clinical symptomatology. Data indicated that, at baseline, reduced levels of antioxidant enzymes were associated with increased plasma lipid peroxides and reduced membrane EPUFAs, particularly omega-3 fatty acids. Furthermore, these biochemical measures normalized after 6 months of antipsychotic treatment. Parallel-improved psychopathology indicated that membrane EPUFA status might be partly affected by oxidative damage, which together may contribute to the pathophysiology and thereby, psychopathology of schizophrenia. These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids.</description><subject>Adult</subject><subject>Alkanes - blood</subject><subject>Antioxidants - therapeutic use</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Drug Therapy, Combination</subject><subject>Erythrocyte Membrane - drug effects</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocytes - enzymology</subject><subject>Essential fatty acids</subject><subject>Fatty Acids, Essential - blood</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Humans</subject><subject>Lipid Peroxides - blood</subject><subject>Membrane phospholipids</subject><subject>Oxidative Stress</subject><subject>Psychotic Disorders - blood</subject><subject>Schizophrenia</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtrHDEUhYVJiNd2fkEgqEo3kytpNI8iRTDxAwwBE9dCI92xtWhWE0kbs_710XoX3LlScb9zxPkI-cKgZsDa7-t68TjpmgOIGvoaGJyQFZOCV7zn4gNZwSB5JXjXn5KzlNYAwBlrPpFT1rRcNANfkZd7tHT0IVhq0Hs64zxGvUGKKeEmO-3ppHPeUW2cLdesx-BdmqnbUNTR7-iSduYpZGfoorMrmUSn4H14dptHqkvFG2Dj9pHmiDrPhbsgHyftE34-vufk4erXn8ub6u739e3lz7vKCClzJbm1re0ma2XDB47t0PcII-8FnzS34yg6I2XbAW_aCc3YAwIbdNMNrNDQiXPy7dC7xPB3iymr2aX92DIzbJPqmOgGIWQBxQE0MaQUcVJLdLOOO8VA7ZWrtXpVrvbKFfSqKC-pr8f67TijfcscHRfgxwHAMvKfw6iSKZ4MWhfRZGWDe_eD_0f0lcw</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Evans, D.R</creator><creator>Parikh, V.V</creator><creator>Khan, M.M</creator><creator>Coussons, C</creator><creator>Buckley, P.F</creator><creator>Mahadik, S.P</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment</title><author>Evans, D.R ; Parikh, V.V ; Khan, M.M ; Coussons, C ; Buckley, P.F ; Mahadik, S.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-52dd6d7fdd54292e6988e0b2832fa2dbb37c55670246fecb80e019a479192e073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Alkanes - blood</topic><topic>Antioxidants - therapeutic use</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Antipsychotics</topic><topic>Drug Therapy, Combination</topic><topic>Erythrocyte Membrane - drug effects</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocytes - enzymology</topic><topic>Essential fatty acids</topic><topic>Fatty Acids, Essential - blood</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Humans</topic><topic>Lipid Peroxides - blood</topic><topic>Membrane phospholipids</topic><topic>Oxidative Stress</topic><topic>Psychotic Disorders - blood</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evans, D.R</creatorcontrib><creatorcontrib>Parikh, V.V</creatorcontrib><creatorcontrib>Khan, M.M</creatorcontrib><creatorcontrib>Coussons, C</creatorcontrib><creatorcontrib>Buckley, P.F</creatorcontrib><creatorcontrib>Mahadik, S.P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evans, D.R</au><au>Parikh, V.V</au><au>Khan, M.M</au><au>Coussons, C</au><au>Buckley, P.F</au><au>Mahadik, S.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>69</volume><issue>6</issue><spage>393</spage><epage>399</epage><pages>393-399</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>A role of indices of oxidative stress, oxidative injury, and abnormal membrane phospholipid, specifically the phospholipid essential polyunsaturated fatty acids (EPUFAs) metabolism has been suggested based on studies in separate groups of patients with or without medication. The current study investigated the relationship between these biochemical measures in first-episode psychotic patients (
N=16) at baseline and after 6 months of antipsychotic treatment (
N=5 each with risperidone and olanzapine) and compared them to matched normal subjects. The indices of oxidative stress included: antioxidant enzymes; superoxide dismutase, glutathione peroxidase and catalase; and the oxidative injury as the levels of plasma lipid peroxides. The key membrane EPUFA's been; linolenic acid, arachidonic acid, nervonic acid, docosapentaenoic acid and docosahexaenoic acid. Furthermore, the changes in these biochemical measures were correlated with clinical symptomatology. Data indicated that, at baseline, reduced levels of antioxidant enzymes were associated with increased plasma lipid peroxides and reduced membrane EPUFAs, particularly omega-3 fatty acids. Furthermore, these biochemical measures normalized after 6 months of antipsychotic treatment. Parallel-improved psychopathology indicated that membrane EPUFA status might be partly affected by oxidative damage, which together may contribute to the pathophysiology and thereby, psychopathology of schizophrenia. These data also support the augmentation of antipsychotic treatment by supplementation with a combination of antioxidants and omega-3 fatty acids.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>14623492</pmid><doi>10.1016/j.plefa.2003.08.010</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Alkanes - blood Antioxidants - therapeutic use Antipsychotic Agents - therapeutic use Antipsychotics Drug Therapy, Combination Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocytes - enzymology Essential fatty acids Fatty Acids, Essential - blood Fatty Acids, Omega-3 - therapeutic use Fatty Acids, Unsaturated - blood Humans Lipid Peroxides - blood Membrane phospholipids Oxidative Stress Psychotic Disorders - blood Schizophrenia |
title | Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment |
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