The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice

Myelin oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of Multiple Sclerosis (MS). Immunization with MOG leads to the development of Experimental Autoimmune Encephalomyelitis (EAE), the experimental model of MS. It ha...

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Veröffentlicht in:	Journal of autoimmunity 2003-12, Vol.21 (4), p.339-351
Hauptverfasser:	Liñares, David, Mañá, Paula, Goodyear, Melinda, Chow, Anne M., Clavarino, Chelsea, Huntington, Nicholas D., Barnett, Louise, Koentgen, Frank, Tomioka, Ryo, Bernard, Claude C.A., Freire-Garabal, Manuel, Reid, Hugh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Autoimmunity - immunology Biological and medical sciences Cell Division Cells, Cultured Cytokines - metabolism EAE Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - physiopathology Gene Deletion General aspects Humans Immunopathology Medical sciences Mice Mice, Knockout Mice, Transgenic MOG Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Myelin Proteins - metabolism Myelin-Associated Glycoprotein - deficiency Myelin-Associated Glycoprotein - genetics Myelin-Associated Glycoprotein - immunology Myelin-Associated Glycoprotein - metabolism Myelin-Oligodendrocyte Glycoprotein Neurology Rats Rats, Sprague-Dawley Spinal Cord - chemistry Spleen - cytology Spleen - metabolism T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Tolerance
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