The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice

Myelin oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of Multiple Sclerosis (MS). Immunization with MOG leads to the development of Experimental Autoimmune Encephalomyelitis (EAE), the experimental model of MS. It ha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of autoimmunity 2003-12, Vol.21 (4), p.339-351
Hauptverfasser: Liñares, David, Mañá, Paula, Goodyear, Melinda, Chow, Anne M., Clavarino, Chelsea, Huntington, Nicholas D., Barnett, Louise, Koentgen, Frank, Tomioka, Ryo, Bernard, Claude C.A., Freire-Garabal, Manuel, Reid, Hugh H.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Myelin oligodendrocyte glycoprotein (MOG) is a minor component of central nervous system myelin presumably implicated in the pathogenesis of Multiple Sclerosis (MS). Immunization with MOG leads to the development of Experimental Autoimmune Encephalomyelitis (EAE), the experimental model of MS. It has been suggested that its encephalitogenic potential may be due to the lack of MOG self-immune tolerance. To clarify this, we have generated a MOG deficient mouse (MOG −/−) strain. Surprisingly, MOG 35–55specific proliferation and Th1-type cytokine production were markedly enhanced in MOG −/−mice compared to wild type control. Furthermore, adoptive transfer of MOG 35–55specific T cells, isolated from MOG deficient mice, into wild-type recipients resulted in the development of a more severe disease, indicating a high capacity of MOG −/−T cells to initiate effector responses. Interestingly, T cell reactivity to overlapping MOG peptides in MOG −/−mice did not reveal new potential immunodominant epitopes in H-2 bmice. Taken together, our data suggests that MOG self-tolerance modulates the encephalitogenic potential of autoreactive MOG T cells in the periphery.
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2003.09.001