Simvastatin Modulates Expression of the PON1 Gene and Increases Serum Paraoxonase: A Role for Sterol Regulatory Element–Binding Protein-2

BACKGROUND—The HDL-associated enzyme paraoxonase protects LDLs from oxidative stress. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) appear to favorably influence the atherosclerotic process by different mechanisms. The present study examined the influence of simvastatin on par...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-11, Vol.23 (11), p.2083-2089
Hauptverfasser:	Deakin, Sara, Leviev, Ilia, Guernier, Sophie, James, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aryldialkylphosphatase - blood Aryldialkylphosphatase - genetics Biological and medical sciences Cells, Cultured Cholesterol - blood Cholesterol, HDL - blood Coronary Disease - drug therapy DNA-Binding Proteins - physiology Dose-Response Relationship, Drug Female Gene Expression Regulation, Enzymologic - drug effects General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Liver - cytology Male Medical sciences Pharmacology. Drug treatments Phenylacetates - blood Promoter Regions, Genetic - drug effects Simvastatin - pharmacology Sterol Regulatory Element Binding Protein 2 Transcription Factors - physiology Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!