Tissue Angiotensin-Converting-Enzyme (ACE) Deficiency Leads to a Reduction in Oxidative Stress and in Atherosclerosis: Studies in ACE-Knockout Mice Type 2

BACKGROUND—Angiotensin II, produced by angiotensin-converting-enzyme (ACE), enhances oxidative stress and atherogenesis. In this study, we analyzed whether tissue ACE deficiency in ACE-knockout mice type-2 would affect their oxidative status. Moreover, by crossbreeding the ACE-knockout mice with ath...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-11, Vol.23 (11), p.2090-2096
Hauptverfasser:	Hayek, Tony, Pavlotzky, Elsa, Hamoud, Shadi, Coleman, Raymond, Keidar, Shlomo, Aviram, Michael, Kaplan, Marielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - enzymology Arteriosclerosis - physiopathology Aryldialkylphosphatase - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cholesterol, LDL - metabolism Lipid Metabolism Lipid Peroxidation - physiology Macrophages, Peritoneal - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Oxidation-Reduction Oxidative Stress - physiology Peptidyl-Dipeptidase A - deficiency Superoxides - metabolism
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