Identification of a novel adrenomedullin gene family in teleost fish
Adrenomedullin (AM) is a multifunctional peptide known to form a hormone family with calcitonin gene-related peptide (CGRP) and amylin. We have cloned five distinct AM cDNAs from the pufferfish, Takifugu rubripes, and named them TrAM-1, -2, -3, -4, and -5. Judging from the deduced precursor sequence...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2003-11, Vol.311 (4), p.1072-1077 |
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| creator | Ogoshi, Maho Inoue, Koji Takei, Yoshio |
| description | Adrenomedullin (AM) is a multifunctional peptide known to form a hormone family with calcitonin gene-related peptide (CGRP) and amylin. We have cloned five distinct AM cDNAs from the pufferfish,
Takifugu rubripes, and named them TrAM-1, -2, -3, -4, and -5. Judging from the deduced precursor sequences and processing pattern of the C-terminal mature peptides, TrAMs may be divided into at least two groups; AM-2 and -3, and AM-1, -4, and possibly -5. Phylogenetic analysis of the mature peptides, exon–intron structure of their genes, and tissue distribution of their mRNA also support this classification. TrAM-1 and -4 were ubiquitously expressed in various tissues including the kidney and interrenal (adrenal homolog) as in the case of mammalian AM, while TrAM-2 and -3 were expressed most abundantly in the brain followed by the vascular tissues. Synteny of the genes around AM gene showed that TrAM-1 is the ortholog of mammalian AM. The presence of a PAMP-like sequence in the prosegment of TrAM-1 also supports this notion. Multiple AMs were also detected in another pufferfish,
Tetraodon nigroviridis, and in zebrafish,
Danio rerio. The present study shows for the first time the presence of a novel AM family in teleost fish that is independent from CGRP and amylin, which further suggests the possible existence of multiple AMs in mammals. |
| doi_str_mv | 10.1016/j.bbrc.2003.10.111 |
| format | Article |
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Takifugu rubripes, and named them TrAM-1, -2, -3, -4, and -5. Judging from the deduced precursor sequences and processing pattern of the C-terminal mature peptides, TrAMs may be divided into at least two groups; AM-2 and -3, and AM-1, -4, and possibly -5. Phylogenetic analysis of the mature peptides, exon–intron structure of their genes, and tissue distribution of their mRNA also support this classification. TrAM-1 and -4 were ubiquitously expressed in various tissues including the kidney and interrenal (adrenal homolog) as in the case of mammalian AM, while TrAM-2 and -3 were expressed most abundantly in the brain followed by the vascular tissues. Synteny of the genes around AM gene showed that TrAM-1 is the ortholog of mammalian AM. The presence of a PAMP-like sequence in the prosegment of TrAM-1 also supports this notion. Multiple AMs were also detected in another pufferfish,
Tetraodon nigroviridis, and in zebrafish,
Danio rerio. The present study shows for the first time the presence of a novel AM family in teleost fish that is independent from CGRP and amylin, which further suggests the possible existence of multiple AMs in mammals.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2003.10.111</identifier><identifier>PMID: 14623291</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenomedullin ; Amino Acid Sequence ; Animals ; Cloning, Molecular ; Comparative genomics ; Conserved Sequence ; Danio rerio ; Evolution, Molecular ; Fishes - genetics ; Fishes - metabolism ; Freshwater ; Gene Expression Profiling - methods ; Gene Expression Regulation - physiology ; Molecular evolution ; Molecular Sequence Data ; Peptides - classification ; Peptides - genetics ; Peptides - metabolism ; Pufferfish ; Sequence Homology ; Species Specificity ; Takifugu - genetics ; Takifugu - metabolism ; Takifugu rubripes ; Teleostei ; Tetraodon nigroviridis ; Tissue Distribution ; Vertebrates - genetics ; Vertebrates - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2003-11, Vol.311 (4), p.1072-1077</ispartof><rights>2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-64f37b14a230ee7fad14d183dbf7e4de7a26225837bfb343a9876aede3b5c873</citedby><cites>FETCH-LOGICAL-c449t-64f37b14a230ee7fad14d183dbf7e4de7a26225837bfb343a9876aede3b5c873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2003.10.111$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14623291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogoshi, Maho</creatorcontrib><creatorcontrib>Inoue, Koji</creatorcontrib><creatorcontrib>Takei, Yoshio</creatorcontrib><title>Identification of a novel adrenomedullin gene family in teleost fish</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Adrenomedullin (AM) is a multifunctional peptide known to form a hormone family with calcitonin gene-related peptide (CGRP) and amylin. We have cloned five distinct AM cDNAs from the pufferfish,
Takifugu rubripes, and named them TrAM-1, -2, -3, -4, and -5. Judging from the deduced precursor sequences and processing pattern of the C-terminal mature peptides, TrAMs may be divided into at least two groups; AM-2 and -3, and AM-1, -4, and possibly -5. Phylogenetic analysis of the mature peptides, exon–intron structure of their genes, and tissue distribution of their mRNA also support this classification. TrAM-1 and -4 were ubiquitously expressed in various tissues including the kidney and interrenal (adrenal homolog) as in the case of mammalian AM, while TrAM-2 and -3 were expressed most abundantly in the brain followed by the vascular tissues. Synteny of the genes around AM gene showed that TrAM-1 is the ortholog of mammalian AM. The presence of a PAMP-like sequence in the prosegment of TrAM-1 also supports this notion. Multiple AMs were also detected in another pufferfish,
Tetraodon nigroviridis, and in zebrafish,
Danio rerio. The present study shows for the first time the presence of a novel AM family in teleost fish that is independent from CGRP and amylin, which further suggests the possible existence of multiple AMs in mammals.</description><subject>Adrenomedullin</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cloning, Molecular</subject><subject>Comparative genomics</subject><subject>Conserved Sequence</subject><subject>Danio rerio</subject><subject>Evolution, Molecular</subject><subject>Fishes - genetics</subject><subject>Fishes - metabolism</subject><subject>Freshwater</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation - physiology</subject><subject>Molecular evolution</subject><subject>Molecular Sequence Data</subject><subject>Peptides - classification</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Pufferfish</subject><subject>Sequence Homology</subject><subject>Species Specificity</subject><subject>Takifugu - genetics</subject><subject>Takifugu - metabolism</subject><subject>Takifugu rubripes</subject><subject>Teleostei</subject><subject>Tetraodon nigroviridis</subject><subject>Tissue Distribution</subject><subject>Vertebrates - genetics</subject><subject>Vertebrates - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWj_-gAfZk7etmSRmd8GL1K9CwYsHbyGbTDRlu9FkW_Dfm7UFb3oaZuaZF-Yh5BzoFCjIq-W0baOZMkr5dJwB7JEJ0IaWDKjYJxNKqSxZA69H5DilJaUAQjaH5CgXxvNiQu7mFvvBO2_04ENfBFfoog8b7AptI_ZhhXbddb4v3rDHwumV776K3A7YYUhD4Xx6PyUHTncJz3b1hLw83L_MnsrF8-N8drsojRDNUErheNWC0IxTxMppC8JCzW3rKhQWK80kY9d1hlzLBddNXUmNFnl7beqKn5DLbexHDJ9rTINa-WSw63SPYZ1UBbySTSP_BUGCrPP7GWRb0MSQUkSnPqJf6filgKrRsVqq0bEaHf_MYDy62KWv22zn92QnNQM3WwCzi43HqJLx2Bu0PqIZlA3-r_xvNQ-NGw</recordid><startdate>20031128</startdate><enddate>20031128</enddate><creator>Ogoshi, Maho</creator><creator>Inoue, Koji</creator><creator>Takei, Yoshio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20031128</creationdate><title>Identification of a novel adrenomedullin gene family in teleost fish</title><author>Ogoshi, Maho ; Inoue, Koji ; Takei, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-64f37b14a230ee7fad14d183dbf7e4de7a26225837bfb343a9876aede3b5c873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenomedullin</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cloning, Molecular</topic><topic>Comparative genomics</topic><topic>Conserved Sequence</topic><topic>Danio rerio</topic><topic>Evolution, Molecular</topic><topic>Fishes - genetics</topic><topic>Fishes - metabolism</topic><topic>Freshwater</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation - physiology</topic><topic>Molecular evolution</topic><topic>Molecular Sequence Data</topic><topic>Peptides - classification</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>Pufferfish</topic><topic>Sequence Homology</topic><topic>Species Specificity</topic><topic>Takifugu - genetics</topic><topic>Takifugu - metabolism</topic><topic>Takifugu rubripes</topic><topic>Teleostei</topic><topic>Tetraodon nigroviridis</topic><topic>Tissue Distribution</topic><topic>Vertebrates - genetics</topic><topic>Vertebrates - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogoshi, Maho</creatorcontrib><creatorcontrib>Inoue, Koji</creatorcontrib><creatorcontrib>Takei, Yoshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogoshi, Maho</au><au>Inoue, Koji</au><au>Takei, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a novel adrenomedullin gene family in teleost fish</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2003-11-28</date><risdate>2003</risdate><volume>311</volume><issue>4</issue><spage>1072</spage><epage>1077</epage><pages>1072-1077</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Adrenomedullin (AM) is a multifunctional peptide known to form a hormone family with calcitonin gene-related peptide (CGRP) and amylin. We have cloned five distinct AM cDNAs from the pufferfish,
Takifugu rubripes, and named them TrAM-1, -2, -3, -4, and -5. Judging from the deduced precursor sequences and processing pattern of the C-terminal mature peptides, TrAMs may be divided into at least two groups; AM-2 and -3, and AM-1, -4, and possibly -5. Phylogenetic analysis of the mature peptides, exon–intron structure of their genes, and tissue distribution of their mRNA also support this classification. TrAM-1 and -4 were ubiquitously expressed in various tissues including the kidney and interrenal (adrenal homolog) as in the case of mammalian AM, while TrAM-2 and -3 were expressed most abundantly in the brain followed by the vascular tissues. Synteny of the genes around AM gene showed that TrAM-1 is the ortholog of mammalian AM. The presence of a PAMP-like sequence in the prosegment of TrAM-1 also supports this notion. Multiple AMs were also detected in another pufferfish,
Tetraodon nigroviridis, and in zebrafish,
Danio rerio. The present study shows for the first time the presence of a novel AM family in teleost fish that is independent from CGRP and amylin, which further suggests the possible existence of multiple AMs in mammals.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14623291</pmid><doi>10.1016/j.bbrc.2003.10.111</doi><tpages>6</tpages></addata></record> |
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| subjects | Adrenomedullin Amino Acid Sequence Animals Cloning, Molecular Comparative genomics Conserved Sequence Danio rerio Evolution, Molecular Fishes - genetics Fishes - metabolism Freshwater Gene Expression Profiling - methods Gene Expression Regulation - physiology Molecular evolution Molecular Sequence Data Peptides - classification Peptides - genetics Peptides - metabolism Pufferfish Sequence Homology Species Specificity Takifugu - genetics Takifugu - metabolism Takifugu rubripes Teleostei Tetraodon nigroviridis Tissue Distribution Vertebrates - genetics Vertebrates - metabolism |
| title | Identification of a novel adrenomedullin gene family in teleost fish |
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