Cortisol levels are positively correlated with hippocampal N-acetylaspartate
This study examined the relationship of hypothalamic–pituitary–adrenal measures and hippocampal N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects. Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spect...
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| Veröffentlicht in: | Biological psychiatry (1969) 2003-11, Vol.54 (10), p.1118-1121 |
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| container_title | Biological psychiatry (1969) |
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| creator | Neylan, Thomas C Schuff, Norbert Lenoci, Maryanne Yehuda, Rachel Weiner, Michael W Marmar, Charles R |
| description | This study examined the relationship of hypothalamic–pituitary–adrenal measures and hippocampal
N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects.
Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spectroscopy as well as by morning salivary cortisol samples before and after administration of low-dose dexamethasone (.5 mg).
Left hippocampal NAA was strongly associated with both pre-dexamethasone cortisol levels (
n = 22,
r = .53,
p = .013) and post-dexamethasone cortisol levels (
n = 22,
r = .63,
p = .002). After accounting for clinical symptom severity and hippocampal volume, cortisol levels accounted for 21.9% of the variance (
F = 5.6,
p = .004) in left hippocampal NAA and 12.6% of the variance (
F = 3.2,
p = .035) in right hippocampal NAA.
This study shows a positive relationship between cortisol levels and hippocampal NAA in subjects without hypercortisolemia. Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus. |
| doi_str_mv | 10.1016/S0006-3223(02)01974-1 |
| format | Article |
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N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects.
Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spectroscopy as well as by morning salivary cortisol samples before and after administration of low-dose dexamethasone (.5 mg).
Left hippocampal NAA was strongly associated with both pre-dexamethasone cortisol levels (
n = 22,
r = .53,
p = .013) and post-dexamethasone cortisol levels (
n = 22,
r = .63,
p = .002). After accounting for clinical symptom severity and hippocampal volume, cortisol levels accounted for 21.9% of the variance (
F = 5.6,
p = .004) in left hippocampal NAA and 12.6% of the variance (
F = 3.2,
p = .035) in right hippocampal NAA.
This study shows a positive relationship between cortisol levels and hippocampal NAA in subjects without hypercortisolemia. Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(02)01974-1</identifier><identifier>PMID: 14625155</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Case-Control Studies ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; cortisol ; Dexamethasone - administration & dosage ; Glucocorticoids - administration & dosage ; hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Humans ; Hydrocortisone - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Middle Aged ; N-acetylaspartate ; Nervous system ; Post-traumatic stress disorder ; Posttraumatic stress disorder ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radioimmunoassay - methods ; Regression Analysis ; Saliva - metabolism ; Statistics as Topic ; Stress Disorders, Post-Traumatic - metabolism ; Veterans</subject><ispartof>Biological psychiatry (1969), 2003-11, Vol.54 (10), p.1118-1121</ispartof><rights>2003 Society of Biological Psychiatry</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-81eee01b88545225895467b9a049bf30e04b1723055c6d27388c2be46db0652e3</citedby><cites>FETCH-LOGICAL-c438t-81eee01b88545225895467b9a049bf30e04b1723055c6d27388c2be46db0652e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322302019741$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15289519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14625155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neylan, Thomas C</creatorcontrib><creatorcontrib>Schuff, Norbert</creatorcontrib><creatorcontrib>Lenoci, Maryanne</creatorcontrib><creatorcontrib>Yehuda, Rachel</creatorcontrib><creatorcontrib>Weiner, Michael W</creatorcontrib><creatorcontrib>Marmar, Charles R</creatorcontrib><title>Cortisol levels are positively correlated with hippocampal N-acetylaspartate</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>This study examined the relationship of hypothalamic–pituitary–adrenal measures and hippocampal
N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects.
Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spectroscopy as well as by morning salivary cortisol samples before and after administration of low-dose dexamethasone (.5 mg).
Left hippocampal NAA was strongly associated with both pre-dexamethasone cortisol levels (
n = 22,
r = .53,
p = .013) and post-dexamethasone cortisol levels (
n = 22,
r = .63,
p = .002). After accounting for clinical symptom severity and hippocampal volume, cortisol levels accounted for 21.9% of the variance (
F = 5.6,
p = .004) in left hippocampal NAA and 12.6% of the variance (
F = 3.2,
p = .035) in right hippocampal NAA.
This study shows a positive relationship between cortisol levels and hippocampal NAA in subjects without hypercortisolemia. Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus.</description><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. Neuroses</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>cortisol</subject><subject>Dexamethasone - administration & dosage</subject><subject>Glucocorticoids - administration & dosage</subject><subject>hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>magnetic resonance spectroscopy</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>N-acetylaspartate</subject><subject>Nervous system</subject><subject>Post-traumatic stress disorder</subject><subject>Posttraumatic stress disorder</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Radioimmunoassay - methods</subject><subject>Regression Analysis</subject><subject>Saliva - metabolism</subject><subject>Statistics as Topic</subject><subject>Stress Disorders, Post-Traumatic - metabolism</subject><subject>Veterans</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotl4eQZmNoovRXCczK5HiDYou1HXIZE5pJG3GJFX69kY76NLV4cD3n8uH0BHBFwST6vIZY1yVjFJ2huk5Jo3kJdlCY1JLVlKO6TYa_yIjtBfjW24lpWQXjQivqCBCjNF04kOy0bvCwQe4WOgARe-jTTa368L4EMDpBF3xadO8mNu-90Yveu2Kx1IbSGunY69DyswB2plpF-FwqPvo9fbmZXJfTp_uHibX09JwVqeyJgCASVvXggtKRd0IXsm20Zg37YxhwLwlkjIshKk6KlldG9oCr7oWV4IC20enm7l98O8riEktbDTgnF6CX0UlCZOV5CyDYgOa4GMMMFN9sAsd1opg9a1R_WhU344UpupHoyI5dzwsWLUL6P5Sg7cMnAyAjka7WdBLY-MfJ2h-ijSZu9pwWS18WAgqGgtLA50NYJLqvP3nlC9xEY4o</recordid><startdate>20031115</startdate><enddate>20031115</enddate><creator>Neylan, Thomas C</creator><creator>Schuff, Norbert</creator><creator>Lenoci, Maryanne</creator><creator>Yehuda, Rachel</creator><creator>Weiner, Michael W</creator><creator>Marmar, Charles R</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031115</creationdate><title>Cortisol levels are positively correlated with hippocampal N-acetylaspartate</title><author>Neylan, Thomas C ; Schuff, Norbert ; Lenoci, Maryanne ; Yehuda, Rachel ; Weiner, Michael W ; Marmar, Charles R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-81eee01b88545225895467b9a049bf30e04b1723055c6d27388c2be46db0652e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Anxiety disorders. Neuroses</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>cortisol</topic><topic>Dexamethasone - administration & dosage</topic><topic>Glucocorticoids - administration & dosage</topic><topic>hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>magnetic resonance spectroscopy</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>N-acetylaspartate</topic><topic>Nervous system</topic><topic>Post-traumatic stress disorder</topic><topic>Posttraumatic stress disorder</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Radioimmunoassay - methods</topic><topic>Regression Analysis</topic><topic>Saliva - metabolism</topic><topic>Statistics as Topic</topic><topic>Stress Disorders, Post-Traumatic - metabolism</topic><topic>Veterans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neylan, Thomas C</creatorcontrib><creatorcontrib>Schuff, Norbert</creatorcontrib><creatorcontrib>Lenoci, Maryanne</creatorcontrib><creatorcontrib>Yehuda, Rachel</creatorcontrib><creatorcontrib>Weiner, Michael W</creatorcontrib><creatorcontrib>Marmar, Charles R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neylan, Thomas C</au><au>Schuff, Norbert</au><au>Lenoci, Maryanne</au><au>Yehuda, Rachel</au><au>Weiner, Michael W</au><au>Marmar, Charles R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortisol levels are positively correlated with hippocampal N-acetylaspartate</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2003-11-15</date><risdate>2003</risdate><volume>54</volume><issue>10</issue><spage>1118</spage><epage>1121</epage><pages>1118-1121</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>This study examined the relationship of hypothalamic–pituitary–adrenal measures and hippocampal
N-acetylaspartate (NAA) in posttraumatic stress disorder (PTSD) patients and control subjects.
Eleven patients with combat-related PTSD and 11 control subjects were evaluated with magnetic resonance spectroscopy as well as by morning salivary cortisol samples before and after administration of low-dose dexamethasone (.5 mg).
Left hippocampal NAA was strongly associated with both pre-dexamethasone cortisol levels (
n = 22,
r = .53,
p = .013) and post-dexamethasone cortisol levels (
n = 22,
r = .63,
p = .002). After accounting for clinical symptom severity and hippocampal volume, cortisol levels accounted for 21.9% of the variance (
F = 5.6,
p = .004) in left hippocampal NAA and 12.6% of the variance (
F = 3.2,
p = .035) in right hippocampal NAA.
This study shows a positive relationship between cortisol levels and hippocampal NAA in subjects without hypercortisolemia. Within the range of values seen in our subjects, cortisol may have a trophic effect on the hippocampus.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14625155</pmid><doi>10.1016/S0006-3223(02)01974-1</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult and adolescent clinical studies Anxiety disorders. Neuroses Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Case-Control Studies Cerebral Cortex - drug effects Cerebral Cortex - metabolism cortisol Dexamethasone - administration & dosage Glucocorticoids - administration & dosage hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans Hydrocortisone - metabolism Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged N-acetylaspartate Nervous system Post-traumatic stress disorder Posttraumatic stress disorder Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry Radioimmunoassay - methods Regression Analysis Saliva - metabolism Statistics as Topic Stress Disorders, Post-Traumatic - metabolism Veterans |
| title | Cortisol levels are positively correlated with hippocampal N-acetylaspartate |
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