Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetes
Nitric oxide (NO) was found to modulate uric acid production through its influence on xanthine oxidase activity, and a close circadian relationship of serum uric acid (SUA) and NO was reported. Studies also revealed that serum NO activity could be determined by endothelial constitutive nitric oxide...
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Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2003-11, Vol.52 (11), p.1448-1453 |
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description | Nitric oxide (NO) was found to modulate uric acid production through its influence on xanthine oxidase activity, and a close circadian relationship of serum uric acid (SUA) and NO was reported. Studies also revealed that serum NO activity could be determined by endothelial constitutive nitric oxide synthase gene (ecNOS) polymorphism. This study was designed to investigate whether SUA could be influenced by a 27-bp repeat polymorphism in intron 4 of ecNOS gene. A total of 398 nondiabetic subjects and 800 patients with type 2 diabetes were studied. The ecNOS gene intron 4 polymorphism was determined by polymerase chain reaction (PCR). The mean SUA level of patients having type 2 diabetes was significantly lower than that of control subjects (6.1 ± 1.8 mg/dL v 6.6 ± 1.8 mg/dL, P < .001); and the mean SUA level of diabetic patients with ecNOS ab/aa genotypes was lower than that of patients with bb genotype (5.7 ± 1.6 mg/dL v 6.2 ± 1.8 mg/dL, P = .008). When subgrouped by gender, the SUA of female diabetic subjects was found to be significantly associated with ecNOS genotype. Using Pearson’s correlation analysis and multiple linear regression analysis, ecNOS genotype was noticed to be an independent factor in contributing to SUA variability in female diabetic patients. Our results suggest that SUA levels may be associated with NO activity and can be genetically predetermined. |
doi_str_mv | 10.1016/S0026-0495(03)00258-0 |
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Studies also revealed that serum NO activity could be determined by endothelial constitutive nitric oxide synthase gene (ecNOS) polymorphism. This study was designed to investigate whether SUA could be influenced by a 27-bp repeat polymorphism in intron 4 of ecNOS gene. A total of 398 nondiabetic subjects and 800 patients with type 2 diabetes were studied. The ecNOS gene intron 4 polymorphism was determined by polymerase chain reaction (PCR). The mean SUA level of patients having type 2 diabetes was significantly lower than that of control subjects (6.1 ± 1.8 mg/dL v 6.6 ± 1.8 mg/dL, P < .001); and the mean SUA level of diabetic patients with ecNOS ab/aa genotypes was lower than that of patients with bb genotype (5.7 ± 1.6 mg/dL v 6.2 ± 1.8 mg/dL, P = .008). When subgrouped by gender, the SUA of female diabetic subjects was found to be significantly associated with ecNOS genotype. Using Pearson’s correlation analysis and multiple linear regression analysis, ecNOS genotype was noticed to be an independent factor in contributing to SUA variability in female diabetic patients. Our results suggest that SUA levels may be associated with NO activity and can be genetically predetermined.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(03)00258-0</identifier><identifier>PMID: 14624405</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Associated diseases and complications ; Biological and medical sciences ; China ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Genotype ; Humans ; Introns - genetics ; Male ; Medical sciences ; Middle Aged ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Polymorphism, Genetic - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sex Characteristics ; Tropical medicine ; Uric Acid - blood</subject><ispartof>Metabolism, clinical and experimental, 2003-11, Vol.52 (11), p.1448-1453</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-eae990468f5ba2b204ccb39ed35e98af300a665a265f372032fa905932f896083</citedby><cites>FETCH-LOGICAL-c443t-eae990468f5ba2b204ccb39ed35e98af300a665a265f372032fa905932f896083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0026-0495(03)00258-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15279840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14624405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yau-Jiunn</creatorcontrib><creatorcontrib>Chang, Dao-Ming</creatorcontrib><creatorcontrib>Tsai, Jack C.R</creatorcontrib><title>Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetes</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Nitric oxide (NO) was found to modulate uric acid production through its influence on xanthine oxidase activity, and a close circadian relationship of serum uric acid (SUA) and NO was reported. Studies also revealed that serum NO activity could be determined by endothelial constitutive nitric oxide synthase gene (ecNOS) polymorphism. This study was designed to investigate whether SUA could be influenced by a 27-bp repeat polymorphism in intron 4 of ecNOS gene. A total of 398 nondiabetic subjects and 800 patients with type 2 diabetes were studied. The ecNOS gene intron 4 polymorphism was determined by polymerase chain reaction (PCR). The mean SUA level of patients having type 2 diabetes was significantly lower than that of control subjects (6.1 ± 1.8 mg/dL v 6.6 ± 1.8 mg/dL, P < .001); and the mean SUA level of diabetic patients with ecNOS ab/aa genotypes was lower than that of patients with bb genotype (5.7 ± 1.6 mg/dL v 6.2 ± 1.8 mg/dL, P = .008). When subgrouped by gender, the SUA of female diabetic subjects was found to be significantly associated with ecNOS genotype. Using Pearson’s correlation analysis and multiple linear regression analysis, ecNOS genotype was noticed to be an independent factor in contributing to SUA variability in female diabetic patients. Our results suggest that SUA levels may be associated with NO activity and can be genetically predetermined.</description><subject>Aged</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Introns - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sex Characteristics</subject><subject>Tropical medicine</subject><subject>Uric Acid - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d2K1TAQB_Aiins8-ghKbhS9qE6TJm2vlmXxCxa8UK9Dmk5tljapmfToeS2f0HbPwb0UApPAL5Mw_yx7XsDbAgr17isAVzmUjXwN4s16kHUOD7JdIQXPawXwMNv9IxfZE6JbAKiqWj3OLopS8bIEucv-XBEF60xywbPQM8N4lbczizijSWwO43EKcR4cTcz5daW4wnKj6LuQBhydGZkNnpJLS3IHZN6l6CwLv12HjI4-DYaQ_UCP7JdLAyOMy8SWzRjrOjbiAUfa2tvBeVwtLe0t2kQnn44zMs46Z1pMSE-zR70ZCZ-d6z77_uH9t-tP-c2Xj5-vr25yW5Yi5WiwaaBUdS9bw1sOpbWtaLATEpva9ALAKCUNV7IXFQfBe9OAbNZaNwpqsc9enfrOMfxckJKeHFkcR-MxLKSrQlRK1sUK5QnaGIgi9nqObjLxqAvQW1j6Liy9JaFB6Luw1s0-e3F-YGkn7O5vndNZwcszMGTN2EfjraN7J3nV1OXW6PLk1jHiwWHUZB16i52L6xh1F9x_vvIXoQ6zkg</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Lee, Yau-Jiunn</creator><creator>Chang, Dao-Ming</creator><creator>Tsai, Jack C.R</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetes</title><author>Lee, Yau-Jiunn ; Chang, Dao-Ming ; Tsai, Jack C.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-eae990468f5ba2b204ccb39ed35e98af300a665a265f372032fa905932f896083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Introns - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sex Characteristics</topic><topic>Tropical medicine</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yau-Jiunn</creatorcontrib><creatorcontrib>Chang, Dao-Ming</creatorcontrib><creatorcontrib>Tsai, Jack C.R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yau-Jiunn</au><au>Chang, Dao-Ming</au><au>Tsai, Jack C.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetes</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>52</volume><issue>11</issue><spage>1448</spage><epage>1453</epage><pages>1448-1453</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Nitric oxide (NO) was found to modulate uric acid production through its influence on xanthine oxidase activity, and a close circadian relationship of serum uric acid (SUA) and NO was reported. Studies also revealed that serum NO activity could be determined by endothelial constitutive nitric oxide synthase gene (ecNOS) polymorphism. This study was designed to investigate whether SUA could be influenced by a 27-bp repeat polymorphism in intron 4 of ecNOS gene. A total of 398 nondiabetic subjects and 800 patients with type 2 diabetes were studied. The ecNOS gene intron 4 polymorphism was determined by polymerase chain reaction (PCR). The mean SUA level of patients having type 2 diabetes was significantly lower than that of control subjects (6.1 ± 1.8 mg/dL v 6.6 ± 1.8 mg/dL, P < .001); and the mean SUA level of diabetic patients with ecNOS ab/aa genotypes was lower than that of patients with bb genotype (5.7 ± 1.6 mg/dL v 6.2 ± 1.8 mg/dL, P = .008). When subgrouped by gender, the SUA of female diabetic subjects was found to be significantly associated with ecNOS genotype. Using Pearson’s correlation analysis and multiple linear regression analysis, ecNOS genotype was noticed to be an independent factor in contributing to SUA variability in female diabetic patients. Our results suggest that SUA levels may be associated with NO activity and can be genetically predetermined.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14624405</pmid><doi>10.1016/S0026-0495(03)00258-0</doi><tpages>6</tpages></addata></record> |
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subjects | Aged Associated diseases and complications Biological and medical sciences China Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genotype Humans Introns - genetics Male Medical sciences Middle Aged Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Polymorphism, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction Sex Characteristics Tropical medicine Uric Acid - blood |
title | Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetes |
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