Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice

Genetic approaches have provided evidence that DNA end-joining problems serve an essential role in neuronal survival during development of mammalian embryos. In the present study, we tested whether the DNA repair enzyme, DNA dependent protein kinase, plays an important role in the survival of cerebr...

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Veröffentlicht in:	Cell death and differentiation 2001-03, Vol.8 (3), p.245-255
Hauptverfasser:	Vemuri, M C, Schiller, E, Naegele, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Blotting, Western Caspase 3 Caspases - metabolism Cell cycle Cell death Cerebral Cortex - cytology Cerebral Cortex - enzymology DNA - genetics DNA - metabolism DNA damage DNA Damage - genetics DNA Damage - physiology DNA repair DNA Repair - physiology DNA-Activated Protein Kinase - metabolism DNA-dependent protein kinase Enzyme Activation Enzymes Female Genes Immune system Immunohistochemistry Immunoprecipitation Kinases Ku antigen Male Mice Mice, SCID Nervous system Neurons - cytology Neurons - enzymology Neurosciences Poly(ADP-ribose) Polymerases - metabolism Proteins
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