Improvement of a mammalian cell culture process by adaptive, model-based dialysis fed-batch cultivation and suppression of apoptosis

Both conventional and genetic engineering techniques can significantly improve the performance of animal cell cultures for the large-scale production of pharmaceutical products. In this paper, the effect of such techniques on cell yield and antibody production of two NS0 cell lines is presented. On...

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Veröffentlicht in:	Bioprocess and biosystems engineering 2003-11, Vol.26 (1), p.1-10
Hauptverfasser:	FRAHM, B, LANE, P, MÄRKI, H, PÖRTNER, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Algorithms Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - immunology Apoptosis Batch processes Biological and medical sciences Bioreactors Biotechnology Cell Culture Techniques - methods Cell Division Cell Line, Tumor Cell Survival Cells Computer Simulation Cultivation Dialysis Dialysis - methods Feedback Fundamental and applied biological sciences. Psychology Genetic engineering Hemodialysis Humans Immunoglobulin G - immunology Mice Models, Biological Multiple Myeloma - pathology Multiple Myeloma - physiopathology Protein Engineering - methods Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Quality Control Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Reproducibility of Results Sensitivity and Specificity
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