Mechanism of acidic pH-induced contraction in spontaneously hypertensive rat aorta: role of Ca2+ release from the sarcoplasmic reticulum

Aim: This study was conducted to investigate the mechanism of acidic pH‐induced contraction (APIC) with regard to Ca2+ handling using isometric tension recording experiments. Results: Decreasing extracellular pH from 7.4 to 6.5 produced a marked and sustained contraction of spontaneously hypertens...

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Veröffentlicht in:	Acta physiologica Scandinavica 2003-11, Vol.179 (3), p.273-280
Hauptverfasser:	Rohra, D. K., Saito, S.-Y., Ohizumi, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	acidosis Acidosis - metabolism Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiopathology Biological and medical sciences Blood vessels and receptors Calcium - metabolism Calcium Channel Blockers - pharmacology calcium release Calcium-Transporting ATPases - metabolism Chelating Agents - pharmacology cyclopiazonic acid Egtazic Acid - pharmacology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Indoles - pharmacology Male Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Rats Rats, Inbred SHR ryanodine Ryanodine - pharmacology ryanodine-sensitive calcium store sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism spontaneously hypertensive rat aorta Verapamil - pharmacology Vertebrates: cardiovascular system
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