Phosphoinositides in yeast: genetically tractable signalling

Research on signalling through phosphoinositides has made tremendous advances over the last few years. Studies with budding yeast ( Saccharomyces cerevisiae) combine the advantage of a eukaryotic system with those of a rapidly growing, genetically modifiable and tractable organism of which the genom...

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Veröffentlicht in:FEMS Yeast Research 2001-04, Vol.1 (1), p.9-13
Hauptverfasser: Wera, Stefaan, Bergsma, Jan C.T., Thevelein, Johan M.
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Bergsma, Jan C.T.
Thevelein, Johan M.
description Research on signalling through phosphoinositides has made tremendous advances over the last few years. Studies with budding yeast ( Saccharomyces cerevisiae) combine the advantage of a eukaryotic system with those of a rapidly growing, genetically modifiable and tractable organism of which the genome is fully sequenced. Hence, despite some differences in phosphoinositide signalling between mammals and yeast (e.g. the absence of PtdIns(3,4,5)P 3), this model organism is at the forefront of phosphoinositide research. In this review we will focus on recent discoveries concerning the role of phosphoinositides in yeast.
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subjects Gene Expression Regulation, Fungal
genome
Inositol
mammals
Phosphatidylinositols - metabolism
Phosphoinositide
phosphoinositides
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Signal Transduction
Type C Phospholipases - genetics
Type C Phospholipases - metabolism
yeasts
title Phosphoinositides in yeast: genetically tractable signalling
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