Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System?
Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this revi...
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| Veröffentlicht in: | Pediatrics (Evanston) 2002-01, Vol.109 (1), p.124-129 |
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| container_title | Pediatrics (Evanston) |
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| creator | Offit, Paul A Quarles, Jessica Gerber, Michael A Hackett, Charles J Marcuse, Edgar K Kollman, Tobias R Gellin, Bruce G Landry, Sarah |
| description | Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this review, we will examine the following: 1) the ontogeny of the active immune response and the ability of neonates and young infants to respond to vaccines; 2) the theoretic capacity of an infant's immune system; 3) data that demonstrate that mild or moderate illness does not interfere with an infant's ability to generate protective immune responses to vaccines; 4) how infants respond to vaccines given in combination compared with the same vaccines given separately; 5) data showing that vaccinated children are not more likely to develop infections with other pathogens than unvaccinated children; and 6) the fact that infants actually encounter fewer antigens in vaccines today than they did 40 or 100 years ago. |
| doi_str_mv | 10.1542/peds.109.1.124 |
| format | Article |
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Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this review, we will examine the following: 1) the ontogeny of the active immune response and the ability of neonates and young infants to respond to vaccines; 2) the theoretic capacity of an infant's immune system; 3) data that demonstrate that mild or moderate illness does not interfere with an infant's ability to generate protective immune responses to vaccines; 4) how infants respond to vaccines given in combination compared with the same vaccines given separately; 5) data showing that vaccinated children are not more likely to develop infections with other pathogens than unvaccinated children; and 6) the fact that infants actually encounter fewer antigens in vaccines today than they did 40 or 100 years ago.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.109.1.124</identifier><identifier>PMID: 11773551</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Adult ; Analysis ; B-Lymphocytes - immunology ; Babies ; Biological and medical sciences ; Children ; Disease Susceptibility - immunology ; Epidemiology. Vaccinations ; General aspects ; Health Knowledge, Attitudes, Practice ; Humans ; Immune system ; Immunity ; Immunity (Physiology) ; Immunity, Maternally-Acquired - immunology ; Immunologic Deficiency Syndromes - immunology ; Infant ; Infant, Newborn ; Infectious diseases ; Medical sciences ; Parents ; Pediatrics ; Vaccination ; Vaccination of children ; Vaccines ; Vaccines, Combined - adverse effects ; Vaccines, Combined - immunology</subject><ispartof>Pediatrics (Evanston), 2002-01, Vol.109 (1), p.124-129</ispartof><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 American Academy of Pediatrics</rights><rights>COPYRIGHT 2002 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Jan 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-982259ce1d0965891c33eb05ae0d489338935ab25f7a42f21fb9b27350fff22c3</citedby><cites>FETCH-LOGICAL-c638t-982259ce1d0965891c33eb05ae0d489338935ab25f7a42f21fb9b27350fff22c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13538313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11773551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Offit, Paul A</creatorcontrib><creatorcontrib>Quarles, Jessica</creatorcontrib><creatorcontrib>Gerber, Michael A</creatorcontrib><creatorcontrib>Hackett, Charles J</creatorcontrib><creatorcontrib>Marcuse, Edgar K</creatorcontrib><creatorcontrib>Kollman, Tobias R</creatorcontrib><creatorcontrib>Gellin, Bruce G</creatorcontrib><creatorcontrib>Landry, Sarah</creatorcontrib><title>Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System?</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. Implicit in this concern is that the infant's immune system is inadequately developed to handle vaccines safely or that multiple vaccines may overwhelm the immune system. In this review, we will examine the following: 1) the ontogeny of the active immune response and the ability of neonates and young infants to respond to vaccines; 2) the theoretic capacity of an infant's immune system; 3) data that demonstrate that mild or moderate illness does not interfere with an infant's ability to generate protective immune responses to vaccines; 4) how infants respond to vaccines given in combination compared with the same vaccines given separately; 5) data showing that vaccinated children are not more likely to develop infections with other pathogens than unvaccinated children; and 6) the fact that infants actually encounter fewer antigens in vaccines today than they did 40 or 100 years ago.</description><subject>Adult</subject><subject>Analysis</subject><subject>B-Lymphocytes - immunology</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Children</subject><subject>Disease Susceptibility - immunology</subject><subject>Epidemiology. Vaccinations</subject><subject>General aspects</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunity (Physiology)</subject><subject>Immunity, Maternally-Acquired - immunology</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Parents</subject><subject>Pediatrics</subject><subject>Vaccination</subject><subject>Vaccination of children</subject><subject>Vaccines</subject><subject>Vaccines, Combined - adverse effects</subject><subject>Vaccines, Combined - immunology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0s2PEyEUAPCJ0bjr6tWjISa6HnYqH0OH8WKaqmuTmpr4dSQM85iyzjAVGNf976Vpk1rTEMKD_OABeVn2lOAJ4QV9vYEmTAiuJmRCaHEvO0-xyAta8vvZOcaM5AXG_Cx7FMINxrjgJX2YnRFSloxzcp7Vs6bxEIJ1LfqsPLgYLtF8cBq8C2_QuwF9GrtoNx2g70pr6yCg1W_wt2voejR49APUT3AorgEtnFEuXga06PvRAfpyFyL0bx9nD4zqAjzZjxfZtw_vv84_5svV9WI-W-Z6ykTMK0EprzSQBldTLiqiGYMacwW4KUTFWOpc1ZSbUhXUUGLqqqbpGdgYQ6lmF9nL3bkbP_waIUTZ26Ch65SDYQyyJGxaUlEk-Pw_eDOM3qW7SUoF40LQKqGrHWpVB9I6M0SvdAsOvOoGB8am5dn2zryotmfmJ3hqDfRWn_KvjnwiEf7EVo0hSHG9PKJXp6geug5akOkP56sjPtlx7YcQPBi58bZX_k4SLLc1I7c1kyaVJDLVTNrwbP8dY91Dc-D7IkngxR6ooFVnvHLahoNjnAlG2CHz2rbrW-thm8mq6K0O_4SHzH8BzfLWqA</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Offit, Paul A</creator><creator>Quarles, Jessica</creator><creator>Gerber, Michael A</creator><creator>Hackett, Charles J</creator><creator>Marcuse, Edgar K</creator><creator>Kollman, Tobias R</creator><creator>Gellin, Bruce G</creator><creator>Landry, Sarah</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System?</title><author>Offit, Paul A ; Quarles, Jessica ; Gerber, Michael A ; Hackett, Charles J ; Marcuse, Edgar K ; Kollman, Tobias R ; Gellin, Bruce G ; Landry, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-982259ce1d0965891c33eb05ae0d489338935ab25f7a42f21fb9b27350fff22c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>B-Lymphocytes - immunology</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Children</topic><topic>Disease Susceptibility - immunology</topic><topic>Epidemiology. Vaccinations</topic><topic>General aspects</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunity (Physiology)</topic><topic>Immunity, Maternally-Acquired - immunology</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Parents</topic><topic>Pediatrics</topic><topic>Vaccination</topic><topic>Vaccination of children</topic><topic>Vaccines</topic><topic>Vaccines, Combined - adverse effects</topic><topic>Vaccines, Combined - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Offit, Paul A</creatorcontrib><creatorcontrib>Quarles, Jessica</creatorcontrib><creatorcontrib>Gerber, Michael A</creatorcontrib><creatorcontrib>Hackett, Charles J</creatorcontrib><creatorcontrib>Marcuse, Edgar K</creatorcontrib><creatorcontrib>Kollman, Tobias R</creatorcontrib><creatorcontrib>Gellin, Bruce G</creatorcontrib><creatorcontrib>Landry, Sarah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Offit, Paul A</au><au>Quarles, Jessica</au><au>Gerber, Michael A</au><au>Hackett, Charles J</au><au>Marcuse, Edgar K</au><au>Kollman, Tobias R</au><au>Gellin, Bruce G</au><au>Landry, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System?</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>109</volume><issue>1</issue><spage>124</spage><epage>129</epage><pages>124-129</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Recent surveys found that an increasing number of parents are concerned that infants receive too many vaccines. 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| subjects | Adult Analysis B-Lymphocytes - immunology Babies Biological and medical sciences Children Disease Susceptibility - immunology Epidemiology. Vaccinations General aspects Health Knowledge, Attitudes, Practice Humans Immune system Immunity Immunity (Physiology) Immunity, Maternally-Acquired - immunology Immunologic Deficiency Syndromes - immunology Infant Infant, Newborn Infectious diseases Medical sciences Parents Pediatrics Vaccination Vaccination of children Vaccines Vaccines, Combined - adverse effects Vaccines, Combined - immunology |
| title | Addressing Parents' Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant's Immune System? |
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