Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract
Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine against RSV is currently available and studies of the natural history of RSV infection suggest repeated infections with antigenically related vi...
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| Veröffentlicht in: | Nature medicine 2002-01, Vol.8 (1), p.54-60 |
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| description | Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine against RSV is currently available and studies of the natural history of RSV infection suggest repeated infections with antigenically related virus strains are common throughout an individual's lifetime. We have studied the CD8
+
T-cell response during experimental murine RSV infection and found that RSV inhibits the expression of effector activity by activated RSV-specific CD8
+
T cells infiltrating the lung parenchyma and the development of pulmonary CD8
+
T-cell memory by interfering with TCR-mediated signaling. These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection. |
| doi_str_mv | 10.1038/nm0102-54 |
| format | Article |
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+
T-cell response during experimental murine RSV infection and found that RSV inhibits the expression of effector activity by activated RSV-specific CD8
+
T cells infiltrating the lung parenchyma and the development of pulmonary CD8
+
T-cell memory by interfering with TCR-mediated signaling. These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm0102-54</identifier><identifier>PMID: 11786907</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Antigens ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Children ; Cytokines ; Female ; Immune Tolerance ; Immunologic Memory ; Immunological memory ; Infants ; Infections ; Infectious Diseases ; Interferon-gamma ; Interleukin-2 - biosynthesis ; Lung - cytology ; Lung - immunology ; Lungs ; Lymphocytes ; Lymphocytes T ; Membrane Glycoproteins - biosynthesis ; Metabolic Diseases ; Mice ; Mice, Inbred BALB C ; Molecular Medicine ; Morbidity ; Neurosciences ; Parenchyma ; Peptides ; Perforin ; Pore Forming Cytotoxic Proteins ; Receptors, Antigen, T-Cell - metabolism ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory tract ; T cell receptors ; Vaccines ; Viruses</subject><ispartof>Nature medicine, 2002-01, Vol.8 (1), p.54-60</ispartof><rights>Springer Nature America, Inc. 2002</rights><rights>COPYRIGHT 2002 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2002</rights><rights>Nature Publishing Group 2002.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-9fe72fd44ed79884d552f0649bc59a605b04d748e955ec7cf29ab1cb39bae02a3</citedby><cites>FETCH-LOGICAL-c547t-9fe72fd44ed79884d552f0649bc59a605b04d748e955ec7cf29ab1cb39bae02a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm0102-54$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm0102-54$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11786907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Jun</creatorcontrib><creatorcontrib>Braciale, Thomas J.</creatorcontrib><title>Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine against RSV is currently available and studies of the natural history of RSV infection suggest repeated infections with antigenically related virus strains are common throughout an individual's lifetime. We have studied the CD8
+
T-cell response during experimental murine RSV infection and found that RSV inhibits the expression of effector activity by activated RSV-specific CD8
+
T cells infiltrating the lung parenchyma and the development of pulmonary CD8
+
T-cell memory by interfering with TCR-mediated signaling. These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection.</description><subject>Animals</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Children</subject><subject>Cytokines</subject><subject>Female</subject><subject>Immune Tolerance</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Interferon-gamma</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Lung - cytology</subject><subject>Lung - immunology</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Medicine</subject><subject>Morbidity</subject><subject>Neurosciences</subject><subject>Parenchyma</subject><subject>Peptides</subject><subject>Perforin</subject><subject>Pore Forming Cytotoxic Proteins</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory tract</subject><subject>T cell receptors</subject><subject>Vaccines</subject><subject>Viruses</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0t2K1DAUB_AiiruOXvgCEhQWVLomzVdzuYxfCwsL6yrelbQ97WRp05qki30Jn9mUGdhZHUF6kdL8zkn65yTJc4JPCab5O9tjgrOUswfJMeFMpETi7w_jO5Z5misujpIn3t9gjCnm6nFyRIjMhcLyOPl1BX40TofBzcjPtpqD0R26NW7yyNgGqmAGi_w0jg68B4-6ybZo_T5_i67TCroOQbOowSEd7a0JM9K2RiM4M27AxWb7uId-OclYFDaA3N7hwcX6p8mjRncenu3WVfL144fr9ef04vLT-frsIq04kyFVDcisqRmDWqo8ZzXnWYMFU2XFlRaYl5jVkuWgOIdKVk2mdEmqkqpSA840XSUn276jG35M4EPRG79cUFsYJl9IQoWgnEb46g94M0zOxrsVmVCcCqIki-rlP1VGSaZojH6VpFvU6g6KmO2w_HILdglpsNCY-PmMKMqElFREf3rAx6eG3lQHC17fK4gmwM_Q6sn74vzL1f_by2_37cme3YDuwsYP3bRMhj_YtHKD9w6aYnSm124uCC6WSS22k1rwJbIXu8imsof6Tu5GM4I3W-Djlm3B3WX6d7ffn9Xu6A</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Chang, Jun</creator><creator>Braciale, Thomas J.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract</title><author>Chang, Jun ; Braciale, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-9fe72fd44ed79884d552f0649bc59a605b04d748e955ec7cf29ab1cb39bae02a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Children</topic><topic>Cytokines</topic><topic>Female</topic><topic>Immune Tolerance</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Interferon-gamma</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Lung - cytology</topic><topic>Lung - immunology</topic><topic>Lungs</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Medicine</topic><topic>Morbidity</topic><topic>Neurosciences</topic><topic>Parenchyma</topic><topic>Peptides</topic><topic>Perforin</topic><topic>Pore Forming Cytotoxic Proteins</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory tract</topic><topic>T cell receptors</topic><topic>Vaccines</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Jun</creatorcontrib><creatorcontrib>Braciale, Thomas J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Jun</au><au>Braciale, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>8</volume><issue>1</issue><spage>54</spage><epage>60</epage><pages>54-60</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine against RSV is currently available and studies of the natural history of RSV infection suggest repeated infections with antigenically related virus strains are common throughout an individual's lifetime. We have studied the CD8
+
T-cell response during experimental murine RSV infection and found that RSV inhibits the expression of effector activity by activated RSV-specific CD8
+
T cells infiltrating the lung parenchyma and the development of pulmonary CD8
+
T-cell memory by interfering with TCR-mediated signaling. These data suggest a possible mechanism to explain the limited duration of protective immunity in RSV infection.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>11786907</pmid><doi>10.1038/nm0102-54</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Animals Antigens Biomedical and Life Sciences Biomedicine Cancer Research CD8 antigen CD8-Positive T-Lymphocytes - immunology Children Cytokines Female Immune Tolerance Immunologic Memory Immunological memory Infants Infections Infectious Diseases Interferon-gamma Interleukin-2 - biosynthesis Lung - cytology Lung - immunology Lungs Lymphocytes Lymphocytes T Membrane Glycoproteins - biosynthesis Metabolic Diseases Mice Mice, Inbred BALB C Molecular Medicine Morbidity Neurosciences Parenchyma Peptides Perforin Pore Forming Cytotoxic Proteins Receptors, Antigen, T-Cell - metabolism Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory tract T cell receptors Vaccines Viruses |
| title | Respiratory syncytial virus infection suppresses lung CD8+ T-cell effector activity and peripheral CD8+ T-cell memory in the respiratory tract |
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