Acute and chronic inflammation in pediatric patients receiving hemodialysis
To assess chronic and acute inflammation in children receiving maintenance hemodialysis. To assess markers of acute inflammation, serum levels (ELISA) of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, and IL-6, 3 to 5 mL of serum was obtained from 13 pediatric patients (mea...
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| Veröffentlicht in: | The Journal of pediatrics 2003-11, Vol.143 (5), p.653-657 |
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| container_title | The Journal of pediatrics |
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| creator | Goldstein, Stuart L Currier, Helen Watters, Lynne Hempe, James M Sheth, Rita D Silverstein, Douglas |
| description | To assess chronic and acute inflammation in children receiving maintenance hemodialysis.
To assess markers of acute inflammation, serum levels (ELISA) of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, and IL-6, 3 to 5 mL of serum was obtained from 13 pediatric patients (mean patient weight, 37.0±15.2 kg; mean age, 14.6±4.6 years) before and 30 minutes and 24 hours after a routine midweek hemodialysis treatment session. Chronic inflammation was assessed by serum C-reactive protein (CRP) levels.
Early-response cytokines TNF-α at 30 minutes (5.84±0.94 to 9.67±0.92 pg/mL; P=.002) and 24 hours (5.84±0.94 to 9.54±1.05 pg/mL; P=.008) and IL-1β at 30 minutes (17.19±2.00 to 26.17±1.12 pg/mL; P=.001) and 24 hours (17.19±2.00 to 23.01±1.13 pg/mL; P=.02) increased significantly after hemodialysis. Later-response cytokines IL-10 and IL-6 activation was not significant. CRP levels were elevated in 10 of 13 patients (mean, 14.7±9.5mg/L; range, 7.2-38.8 mg/L) and correlated with dialysis vintage. Baseline IL-6 and IL-10 levels correlated with dialysis vintage and correlated negatively with eqKt/V.
We observed a chronic inflammatory state in pediatric hemodialysis patients not related to the hemodialysis treatment but rather dialysis vintage and hemodialysis adequacy. We suggest that either more frequent dialysis or enhanced cytokine clearance may ameliorate the chronic inflammatory state observed in pediatric patients receiving hemodialysis. |
| doi_str_mv | 10.1067/S0022-3476(03)00534-1 |
| format | Article |
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To assess markers of acute inflammation, serum levels (ELISA) of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, and IL-6, 3 to 5 mL of serum was obtained from 13 pediatric patients (mean patient weight, 37.0±15.2 kg; mean age, 14.6±4.6 years) before and 30 minutes and 24 hours after a routine midweek hemodialysis treatment session. Chronic inflammation was assessed by serum C-reactive protein (CRP) levels.
Early-response cytokines TNF-α at 30 minutes (5.84±0.94 to 9.67±0.92 pg/mL; P=.002) and 24 hours (5.84±0.94 to 9.54±1.05 pg/mL; P=.008) and IL-1β at 30 minutes (17.19±2.00 to 26.17±1.12 pg/mL; P=.001) and 24 hours (17.19±2.00 to 23.01±1.13 pg/mL; P=.02) increased significantly after hemodialysis. Later-response cytokines IL-10 and IL-6 activation was not significant. CRP levels were elevated in 10 of 13 patients (mean, 14.7±9.5mg/L; range, 7.2-38.8 mg/L) and correlated with dialysis vintage. Baseline IL-6 and IL-10 levels correlated with dialysis vintage and correlated negatively with eqKt/V.
We observed a chronic inflammatory state in pediatric hemodialysis patients not related to the hemodialysis treatment but rather dialysis vintage and hemodialysis adequacy. We suggest that either more frequent dialysis or enhanced cytokine clearance may ameliorate the chronic inflammatory state observed in pediatric patients receiving hemodialysis.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1067/S0022-3476(03)00534-1</identifier><identifier>PMID: 14615740</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Child ; Child, Preschool ; Chronic Disease ; Cytokines - blood ; Cytokines - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastroesophageal Reflux - epidemiology ; Gastroesophageal Reflux - therapy ; Glomerulosclerosis, Focal Segmental - epidemiology ; Glomerulosclerosis, Focal Segmental - therapy ; Humans ; Inflammation - epidemiology ; Inflammation - immunology ; Lupus Erythematosus, Systemic - epidemiology ; Lupus Erythematosus, Systemic - therapy ; Male ; Renal Dialysis - methods</subject><ispartof>The Journal of pediatrics, 2003-11, Vol.143 (5), p.653-657</ispartof><rights>2003 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-7f1368d9377f03b276b1a720b644fbed97431f55a17ccc0a378b514abe864a763</citedby><cites>FETCH-LOGICAL-c361t-7f1368d9377f03b276b1a720b644fbed97431f55a17ccc0a378b514abe864a763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347603005341$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14615740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldstein, Stuart L</creatorcontrib><creatorcontrib>Currier, Helen</creatorcontrib><creatorcontrib>Watters, Lynne</creatorcontrib><creatorcontrib>Hempe, James M</creatorcontrib><creatorcontrib>Sheth, Rita D</creatorcontrib><creatorcontrib>Silverstein, Douglas</creatorcontrib><title>Acute and chronic inflammation in pediatric patients receiving hemodialysis</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To assess chronic and acute inflammation in children receiving maintenance hemodialysis.
To assess markers of acute inflammation, serum levels (ELISA) of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, and IL-6, 3 to 5 mL of serum was obtained from 13 pediatric patients (mean patient weight, 37.0±15.2 kg; mean age, 14.6±4.6 years) before and 30 minutes and 24 hours after a routine midweek hemodialysis treatment session. Chronic inflammation was assessed by serum C-reactive protein (CRP) levels.
Early-response cytokines TNF-α at 30 minutes (5.84±0.94 to 9.67±0.92 pg/mL; P=.002) and 24 hours (5.84±0.94 to 9.54±1.05 pg/mL; P=.008) and IL-1β at 30 minutes (17.19±2.00 to 26.17±1.12 pg/mL; P=.001) and 24 hours (17.19±2.00 to 23.01±1.13 pg/mL; P=.02) increased significantly after hemodialysis. Later-response cytokines IL-10 and IL-6 activation was not significant. CRP levels were elevated in 10 of 13 patients (mean, 14.7±9.5mg/L; range, 7.2-38.8 mg/L) and correlated with dialysis vintage. Baseline IL-6 and IL-10 levels correlated with dialysis vintage and correlated negatively with eqKt/V.
We observed a chronic inflammatory state in pediatric hemodialysis patients not related to the hemodialysis treatment but rather dialysis vintage and hemodialysis adequacy. We suggest that either more frequent dialysis or enhanced cytokine clearance may ameliorate the chronic inflammatory state observed in pediatric patients receiving hemodialysis.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Cytokines - blood</subject><subject>Cytokines - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gastroesophageal Reflux - epidemiology</subject><subject>Gastroesophageal Reflux - therapy</subject><subject>Glomerulosclerosis, Focal Segmental - epidemiology</subject><subject>Glomerulosclerosis, Focal Segmental - therapy</subject><subject>Humans</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - immunology</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lupus Erythematosus, Systemic - therapy</subject><subject>Male</subject><subject>Renal Dialysis - methods</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAMgCMEYmPwE0A9ITgUnCZN2hOaJl5iEgfgHKWpy4L6GEk7af-e7CE4crJsf7blj5BzCjcUhLx9A0iSmHEproBdA6SMx_SAjCnkMhYZY4dk_IuMyIn3XwCQc4BjMqJc0FRyGJOXqRl6jHRbRmbhutaayLZVrZtG97ZrQxItsbS6d6GzDDVsex85NGhXtv2MFth0oV2vvfWn5KjStcezfZyQj4f799lTPH99fJ5N57FhgvaxrCgTWZkzKStgRSJFQbVMoBCcVwWWueSMVmmqqTTGgGYyK1LKdYGZ4FoKNiGXu71L130P6HvVWG-wrnWL3eCVDPtFAjKA6Q40rvPeYaWWzjbarRUFtbGothbVRpECprYWFQ1zF_sDQ9Fg-Te11xaAux2A4c2VRae8CWZMMBXU9Krs7D8nfgC39YGL</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Goldstein, Stuart L</creator><creator>Currier, Helen</creator><creator>Watters, Lynne</creator><creator>Hempe, James M</creator><creator>Sheth, Rita D</creator><creator>Silverstein, Douglas</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Acute and chronic inflammation in pediatric patients receiving hemodialysis</title><author>Goldstein, Stuart L ; Currier, Helen ; Watters, Lynne ; Hempe, James M ; Sheth, Rita D ; Silverstein, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-7f1368d9377f03b276b1a720b644fbed97431f55a17ccc0a378b514abe864a763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Cytokines - blood</topic><topic>Cytokines - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gastroesophageal Reflux - epidemiology</topic><topic>Gastroesophageal Reflux - therapy</topic><topic>Glomerulosclerosis, Focal Segmental - epidemiology</topic><topic>Glomerulosclerosis, Focal Segmental - therapy</topic><topic>Humans</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - immunology</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lupus Erythematosus, Systemic - therapy</topic><topic>Male</topic><topic>Renal Dialysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldstein, Stuart L</creatorcontrib><creatorcontrib>Currier, Helen</creatorcontrib><creatorcontrib>Watters, Lynne</creatorcontrib><creatorcontrib>Hempe, James M</creatorcontrib><creatorcontrib>Sheth, Rita D</creatorcontrib><creatorcontrib>Silverstein, Douglas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldstein, Stuart L</au><au>Currier, Helen</au><au>Watters, Lynne</au><au>Hempe, James M</au><au>Sheth, Rita D</au><au>Silverstein, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and chronic inflammation in pediatric patients receiving hemodialysis</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>143</volume><issue>5</issue><spage>653</spage><epage>657</epage><pages>653-657</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>To assess chronic and acute inflammation in children receiving maintenance hemodialysis.
To assess markers of acute inflammation, serum levels (ELISA) of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, and IL-6, 3 to 5 mL of serum was obtained from 13 pediatric patients (mean patient weight, 37.0±15.2 kg; mean age, 14.6±4.6 years) before and 30 minutes and 24 hours after a routine midweek hemodialysis treatment session. Chronic inflammation was assessed by serum C-reactive protein (CRP) levels.
Early-response cytokines TNF-α at 30 minutes (5.84±0.94 to 9.67±0.92 pg/mL; P=.002) and 24 hours (5.84±0.94 to 9.54±1.05 pg/mL; P=.008) and IL-1β at 30 minutes (17.19±2.00 to 26.17±1.12 pg/mL; P=.001) and 24 hours (17.19±2.00 to 23.01±1.13 pg/mL; P=.02) increased significantly after hemodialysis. Later-response cytokines IL-10 and IL-6 activation was not significant. CRP levels were elevated in 10 of 13 patients (mean, 14.7±9.5mg/L; range, 7.2-38.8 mg/L) and correlated with dialysis vintage. Baseline IL-6 and IL-10 levels correlated with dialysis vintage and correlated negatively with eqKt/V.
We observed a chronic inflammatory state in pediatric hemodialysis patients not related to the hemodialysis treatment but rather dialysis vintage and hemodialysis adequacy. We suggest that either more frequent dialysis or enhanced cytokine clearance may ameliorate the chronic inflammatory state observed in pediatric patients receiving hemodialysis.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>14615740</pmid><doi>10.1067/S0022-3476(03)00534-1</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute Disease Adolescent Adult Child Child, Preschool Chronic Disease Cytokines - blood Cytokines - immunology Enzyme-Linked Immunosorbent Assay Female Gastroesophageal Reflux - epidemiology Gastroesophageal Reflux - therapy Glomerulosclerosis, Focal Segmental - epidemiology Glomerulosclerosis, Focal Segmental - therapy Humans Inflammation - epidemiology Inflammation - immunology Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - therapy Male Renal Dialysis - methods |
| title | Acute and chronic inflammation in pediatric patients receiving hemodialysis |
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