Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins

Inhibition of alphavbeta3 or alphavbeta5 integrin function has been reported to suppress neovascularization and tumor growth, suggesting that these integrins are critical modulators of angiogenesis. Here we report that mice lacking beta3 integrins or both beta3 and beta5 integrins not only support t...

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Veröffentlicht in:	Nature medicine 2002-01, Vol.8 (1), p.27-34
Hauptverfasser:	Reynolds, Louise E, Wyder, Lorenza, Lively, Julie C, Taverna, Daniela, Robinson, Stephen D, Huang, Xiaozhu, Sheppard, Dean, Hynes, Richard O, Hodivala-Dilke, Kairbaan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Endothelial Growth Factors - pharmacology Endothelium, Vascular - drug effects Integrin beta Chains Integrin beta3 Integrins - deficiency Integrins - genetics Integrins - metabolism Lymphokines - pharmacology Mice Mice, Mutant Strains Neoplasms, Experimental - blood supply Neovascularization, Pathologic - etiology Platelet Membrane Glycoproteins - deficiency Platelet Membrane Glycoproteins - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor Receptors, Vitronectin - metabolism Retinal Neovascularization Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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