Regulation of Cortical Dendrite Development by Slit-Robo Interactions
Slit proteins have previously been shown to regulate axon guidance, branching, and neural migration. Here we report that, in addition to acting as a chemorepellant for cortical axons, Slit1 regulates dendritic development. Slit1 is expressed in the developing cortex, and exposure to Slit1 leads to i...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2002-01, Vol.33 (1), p.47-61 |
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| creator | Whitford, Kristin L. Marillat, Valérie Stein, Elke Goodman, Corey S. Tessier-Lavigne, Marc Chédotal, Alain Ghosh, Anirvan |
| description | Slit proteins have previously been shown to regulate axon guidance, branching, and neural migration. Here we report that, in addition to acting as a chemorepellant for cortical axons, Slit1 regulates dendritic development. Slit1 is expressed in the developing cortex, and exposure to Slit1 leads to increased dendritic growth and branching. Conversely, inhibition of Slit-Robo interactions by Robo-Fc fusion proteins or by a dominant-negative Robo attenuates dendritic branching. Stimulation of neurons transfected with a Met-Robo chimeric receptor with Hepatocyte growth factor leads to a robust induction of dendritic growth and branching, suggesting that Robo-mediated signaling is sufficient to induce dendritic remodeling. These experiments indicate that Slit-Robo interactions may exert a significant influence over the specification of cortical neuron morphology by regulating both axon guidance and dendritic patterning. |
| doi_str_mv | 10.1016/S0896-6273(01)00566-9 |
| format | Article |
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Here we report that, in addition to acting as a chemorepellant for cortical axons, Slit1 regulates dendritic development. Slit1 is expressed in the developing cortex, and exposure to Slit1 leads to increased dendritic growth and branching. Conversely, inhibition of Slit-Robo interactions by Robo-Fc fusion proteins or by a dominant-negative Robo attenuates dendritic branching. Stimulation of neurons transfected with a Met-Robo chimeric receptor with Hepatocyte growth factor leads to a robust induction of dendritic growth and branching, suggesting that Robo-mediated signaling is sufficient to induce dendritic remodeling. 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| subjects | Animals Brain Cell Communication - physiology Cell Differentiation - physiology Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Chemotaxis - genetics Dendrites - metabolism Dendrites - ultrastructure Fetus Gene Expression Regulation, Developmental - physiology Insects Intercellular Signaling Peptides and Proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Peptide Fragments - genetics Peptide Fragments - metabolism Protein Structure, Tertiary - physiology Rats Rats, Long-Evans Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Robo protein Rodents Roundabout Proteins Signal Transduction - genetics Slit1 protein Software Transfection |
| title | Regulation of Cortical Dendrite Development by Slit-Robo Interactions |
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