Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury
Jacobs PL, Mahoney ET, Cohn KA, Sheradsky LF, Green BA. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil 2002;83:19-23. Objective: To examine the effects of short-term creatine monohydrate supplementation on...
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| description | Jacobs PL, Mahoney ET, Cohn KA, Sheradsky LF, Green BA. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil 2002;83:19-23. Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to 1 of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (V̇O2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of VO2, VCO2, and VT at peak effort after creatine supplementation (P |
| doi_str_mv | 10.1053/apmr.2002.26829 |
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Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil 2002;83:19-23. Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to 1 of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (V̇O2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of VO2, VCO2, and VT at peak effort after creatine supplementation (P <.001). Conclusions: Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1053/apmr.2002.26829</identifier><identifier>PMID: 11782827</identifier><identifier>CODEN: APMHAI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Adult ; Analysis of Variance ; Arm - physiology ; Biological and medical sciences ; Cervical Vertebrae - injuries ; Creatine ; Creatine - therapeutic use ; Cross-Over Studies ; Dietary supplementation ; Diseases of the nervous system ; Double-Blind Method ; Exercise tolerance ; Exercise Tolerance - drug effects ; Humans ; Medical sciences ; Middle Aged ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rehabilitation ; Spinal cord injuries ; Spinal Cord Injuries - physiopathology ; Spinal Cord Injuries - rehabilitation</subject><ispartof>Archives of physical medicine and rehabilitation, 2002-01, Vol.83 (1), p.19-23</ispartof><rights>2002 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-f9212f6938f30342249e82d4ed99403fc5e1fb28bb6222c4cecffcda831954e93</citedby><cites>FETCH-LOGICAL-c404t-f9212f6938f30342249e82d4ed99403fc5e1fb28bb6222c4cecffcda831954e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003999302923130$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13442814$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11782827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobs, Patrick L.</creatorcontrib><creatorcontrib>Mahoney, Edward T.</creatorcontrib><creatorcontrib>Cohn, Kelly A.</creatorcontrib><creatorcontrib>Sheradsky, Laurey F.</creatorcontrib><creatorcontrib>Green, Barth A.</creatorcontrib><title>Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>Jacobs PL, Mahoney ET, Cohn KA, Sheradsky LF, Green BA. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil 2002;83:19-23. Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to 1 of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (V̇O2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of VO2, VCO2, and VT at peak effort after creatine supplementation (P <.001). Conclusions: Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Arm - physiology</subject><subject>Biological and medical sciences</subject><subject>Cervical Vertebrae - injuries</subject><subject>Creatine</subject><subject>Creatine - therapeutic use</subject><subject>Cross-Over Studies</subject><subject>Dietary supplementation</subject><subject>Diseases of the nervous system</subject><subject>Double-Blind Method</subject><subject>Exercise tolerance</subject><subject>Exercise Tolerance - drug effects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Rehabilitation</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - rehabilitation</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv3CAQRlHVqNlueu6t4tLevIEBe-FYRWlTKVIujZQbYvGgkNrYBXuT_ffF3ZVyqnoBDTxm0PcI-cjZhrNaXNqxTxtgDDbQKNBvyIrXAioF_OEtWTHGRKW1Fufkfc5PpWxqwd-Rc863ChRsV2R_l2xHXUI7hYg0z-PYYY9xKvUQKcZHGx1mWs4xUXyZEvZhOtDnIf2izo7WLVWItFznIWb6HKZH6jDtg7Nd1eEeO5rHEJcpQ2oL-jSnwwU587bL-OG0r8n9t-ufVzfV7d33H1dfbysnmZwqr4GDb7RQXjAhAaRGBa3EVmvJhHc1cr8Dtds1AOCkQ-e9a60SXNcStViTL8e-Yxp-z5gn04fssOtsxGHOZstFU_O6_i_IlRBbKMuaXB5Bl4acE3ozptDbdDCcmcWJWZyYxYn566S8-HRqPe96bF_5k4QCfD4BNpfQfCqRh_zKCSlBcVk4feSwJLYPmEx2AYueNiR0k2mH8M9P_AFInash</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Jacobs, Patrick L.</creator><creator>Mahoney, Edward T.</creator><creator>Cohn, Kelly A.</creator><creator>Sheradsky, Laurey F.</creator><creator>Green, Barth A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury</title><author>Jacobs, Patrick L. ; Mahoney, Edward T. ; Cohn, Kelly A. ; Sheradsky, Laurey F. ; Green, Barth A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-f9212f6938f30342249e82d4ed99403fc5e1fb28bb6222c4cecffcda831954e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Arm - physiology</topic><topic>Biological and medical sciences</topic><topic>Cervical Vertebrae - injuries</topic><topic>Creatine</topic><topic>Creatine - therapeutic use</topic><topic>Cross-Over Studies</topic><topic>Dietary supplementation</topic><topic>Diseases of the nervous system</topic><topic>Double-Blind Method</topic><topic>Exercise tolerance</topic><topic>Exercise Tolerance - drug effects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Rehabilitation</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal Cord Injuries - rehabilitation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobs, Patrick L.</creatorcontrib><creatorcontrib>Mahoney, Edward T.</creatorcontrib><creatorcontrib>Cohn, Kelly A.</creatorcontrib><creatorcontrib>Sheradsky, Laurey F.</creatorcontrib><creatorcontrib>Green, Barth A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacobs, Patrick L.</au><au>Mahoney, Edward T.</au><au>Cohn, Kelly A.</au><au>Sheradsky, Laurey F.</au><au>Green, Barth A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2002-01</date><risdate>2002</risdate><volume>83</volume><issue>1</issue><spage>19</spage><epage>23</epage><pages>19-23</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><coden>APMHAI</coden><abstract>Jacobs PL, Mahoney ET, Cohn KA, Sheradsky LF, Green BA. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil 2002;83:19-23. Objective: To examine the effects of short-term creatine monohydrate supplementation on the upper extremity work capacity of persons with cervical-level spinal cord injury (SCI). Design: Randomized, double-blind, placebo-controlled, crossover design study. Consists of 2 treatment phases lasting for 7 days, separated by a 21-day washout period. Setting: University research laboratory trial. Participants: Sixteen men with complete cervical-level SCI (C5-7). Intervention: Subjects were randomly assigned to 1 of 2 groups and received either 20g/d of creatine monohydrate supplement powder or placebo maltodextrin powder for the first treatment phase; the treatment was reversed in the second phase. Incremental peak arm ergometry tests, using 2-minute work stages and 1-minute recovery periods, were performed immediately before and after each treatment phase (total of 4 assessments). The initial stage was performed unloaded, with power output progressively increased 10 watts/stage until subjects had achieved volitional exhaustion. Main Outcome Measures: Peak power output, time to fatigue, heart rate, and metabolic measurements, including oxygen uptake (V̇O2), minute ventilation, tidal volume (VT), and respiration frequency. Results: Significantly greater values of VO2, VCO2, and VT at peak effort after creatine supplementation (P <.001). Conclusions: Creatine supplementation enhances the exercise capacity in persons with complete cervical-level SCI and may promote greater exercise training benefits. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11782827</pmid><doi>10.1053/apmr.2002.26829</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Administration, Oral Adult Analysis of Variance Arm - physiology Biological and medical sciences Cervical Vertebrae - injuries Creatine Creatine - therapeutic use Cross-Over Studies Dietary supplementation Diseases of the nervous system Double-Blind Method Exercise tolerance Exercise Tolerance - drug effects Humans Medical sciences Middle Aged Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rehabilitation Spinal cord injuries Spinal Cord Injuries - physiopathology Spinal Cord Injuries - rehabilitation |
| title | Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury |
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