Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni
Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)–α, and immune complexes were measured in serum...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-01, Vol.185 (1), p.98-105 |
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| creator | de Jesus, Amelia Ribeiro Silva, Angela Santana, Luciana B. Magalhães, Andrea de Jesus, Adriana Almeida de Almeida, Roque Pacheco Rêgo, Marco A. V. Burattini, Marcelo N. Pearce, Edward J. Carvalho, Edgar M. |
| description | Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)–α, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean±SD, 7.8±7.6 μg Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean ± SD) of TNF-α (1349.3±767.6 pg/mL), interleukin (IL)–1 (2683±1270 pg/mL), and IL-6 (382 ± 52.3 pg/mL) were elevated in PBMC. Serum TNF-α levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-γ levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis |
| doi_str_mv | 10.1086/324668 |
| format | Article |
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Levels (mean ± SD) of TNF-α (1349.3±767.6 pg/mL), interleukin (IL)–1 (2683±1270 pg/mL), and IL-6 (382 ± 52.3 pg/mL) were elevated in PBMC. Serum TNF-α levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-γ levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. 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V.</creatorcontrib><creatorcontrib>Burattini, Marcelo N.</creatorcontrib><creatorcontrib>Pearce, Edward J.</creatorcontrib><creatorcontrib>Carvalho, Edgar M.</creatorcontrib><title>Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)–α, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean±SD, 7.8±7.6 μg Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean ± SD) of TNF-α (1349.3±767.6 pg/mL), interleukin (IL)–1 (2683±1270 pg/mL), and IL-6 (382 ± 52.3 pg/mL) were elevated in PBMC. Serum TNF-α levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-γ levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis</description><subject>Acute Disease</subject><subject>Acute diseases</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antigen antibody complex</subject><subject>Antigen-Antibody Complex - blood</subject><subject>Antigens</subject><subject>Antigens, Helminth - blood</subject><subject>Biological and medical sciences</subject><subject>Brazil - epidemiology</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Chronic diseases</subject><subject>Cytokines</subject><subject>Cytokines - secretion</subject><subject>Diseases caused by trematodes</subject><subject>Endemic Diseases</subject><subject>Feces - parasitology</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Parasite Egg Count</subject><subject>Parasitic diseases</subject><subject>Patient assessment</subject><subject>Schistosomiases</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis mansoni - epidemiology</subject><subject>Schistosomiasis mansoni - etiology</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Symptoms</subject><subject>Water - parasitology</subject><subject>Water Supply</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10V1rFDEUBuAgil2r_gMlCno3mpMzm2Quy9LaQkXFVsSbkMkkNutMsk5m_Pj3RmbpguBVCOfhTXgPIY-BvQKmxGvktRDqDlnBGmUlBOBdsmKM8wpU0xyRBzlvGWM1CnmfHAHItWiUXJHrTR9isKanJnb0YhjmmPr0NVh6-sP0s5lCijR5ikDfl4uLU6Y_w3RDT-w8OfrR3oQ8pZyGYHLIdDAxpxgeknve9Nk92p_H5Prs9GpzXl2-e3OxObmsbL1mUyV4p6yXneQMpBdeddipFn3TOVRdLViHvpZNawBa3qGwvvEGfA3ONpZhi8fk5ZK7G9P32eVJDyFb1_cmujRnLQFFDY0o8Pk_cJvmMZa_ac5RNWtU_JBmx5Tz6LzejWEw428NTP9tWS8tF_h0nza3g-sObF9rAS_2wOTSrR9NtCEfHNYcJGPFPVtcmnf_f-zJYral6PFWIQNUgFDm1TIvi3C_budm_KaFRLnW55-_aPGB15-u3oI-wz8UqaXf</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>de Jesus, Amelia Ribeiro</creator><creator>Silva, Angela</creator><creator>Santana, Luciana B.</creator><creator>Magalhães, Andrea</creator><creator>de Jesus, Adriana Almeida</creator><creator>de Almeida, Roque Pacheco</creator><creator>Rêgo, Marco A. V.</creator><creator>Burattini, Marcelo N.</creator><creator>Pearce, Edward J.</creator><creator>Carvalho, Edgar M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni</title><author>de Jesus, Amelia Ribeiro ; Silva, Angela ; Santana, Luciana B. ; Magalhães, Andrea ; de Jesus, Adriana Almeida ; de Almeida, Roque Pacheco ; Rêgo, Marco A. 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V.</au><au>Burattini, Marcelo N.</au><au>Pearce, Edward J.</au><au>Carvalho, Edgar M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>185</volume><issue>1</issue><spage>98</spage><epage>105</epage><pages>98-105</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)–α, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean±SD, 7.8±7.6 μg Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean ± SD) of TNF-α (1349.3±767.6 pg/mL), interleukin (IL)–1 (2683±1270 pg/mL), and IL-6 (382 ± 52.3 pg/mL) were elevated in PBMC. Serum TNF-α levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-γ levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11756987</pmid><doi>10.1086/324668</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Acute Disease Acute diseases Adolescent Adult Antigen antibody complex Antigen-Antibody Complex - blood Antigens Antigens, Helminth - blood Biological and medical sciences Brazil - epidemiology Child Chronic Disease Chronic diseases Cytokines Cytokines - secretion Diseases caused by trematodes Endemic Diseases Feces - parasitology Helminthic diseases Humans Immunoglobulin E - blood Immunology Infections Infectious diseases Leukocytes, Mononuclear - immunology Major Articles Medical sciences Parasite Egg Count Parasitic diseases Patient assessment Schistosomiases Schistosomiasis Schistosomiasis mansoni - epidemiology Schistosomiasis mansoni - etiology Schistosomiasis mansoni - immunology Symptoms Water - parasitology Water Supply |
| title | Clinical and Immunologic Evaluation of 31 Patients with Acute Schistosomiasis mansoni |
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