DNA Damage-induced MDMX Degradation Is Mediated by MDM2

Although genetic studies have demonstrated that MDMX is essential to maintain p53 activity at low levels in non-stressed cells, it is unknown whether MDMX regulates p53 activation by DNA damage. We show here that DNA damage-induced p53 induction is associated with rapid down-regulation of the MDMX p...

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Veröffentlicht in:	The Journal of biological chemistry 2003-11, Vol.278 (46), p.45946-45953
Hauptverfasser:	Kawai, Hidehiko, Wiederschain, Dmitri, Kitao, Hiroyuki, Stuart, Jeremy, Tsai, Kelvin K.C., Yuan, Zhi-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Cycle Cell Line, Tumor Cysteine Endopeptidases - metabolism DNA Damage Down-Regulation Humans MDM2 protein MDMX protein Microscopy, Fluorescence Multienzyme Complexes - metabolism Nuclear Proteins Plasmids - metabolism Precipitin Tests Proteasome Endopeptidase Complex Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction Time Factors Transfection Tumor Suppressor Protein p53 - metabolism Ubiquitin - metabolism
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