Anti-Helicobacter pylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole Analogues

To extend the SAR study of guanidinothiazoles as a structurally novel class of anti-H. pylori agents, a series of 2-(substituted guanidino)-4-arylthiazoles and some 4-aryloxazole analogues were synthesized and evaluated for antimicrobial activity against H. pylori. Some of them were also subjected t...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-01, Vol.45 (1), p.143-150
Hauptverfasser:	KATSURA, Yousuke, NISHINO, Shigetaka, INOUE, Yoshikazu, SAKANE, Kazuo, MATSUMOTO, Yoshimi, MORINAGA, Chizu, ISHIKAWA, Hirohumi, TAKASUGI, Hisashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Colony Count, Microbial Gastric Juice - metabolism Guanidines - chemical synthesis Guanidines - chemistry Guanidines - pharmacology Guinea Pigs Helicobacter pylori - drug effects Histamine H2 Antagonists - chemical synthesis Histamine H2 Antagonists - chemistry Histamine H2 Antagonists - pharmacology In Vitro Techniques Male Medical sciences Microbial Sensitivity Tests Myocardium - metabolism Oxazoles - chemical synthesis Oxazoles - chemistry Oxazoles - pharmacology Pharmacology. Drug treatments Rats Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Thiophenes - chemical synthesis Thiophenes - chemistry Thiophenes - pharmacology
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