Activities of drug metabolizing enzymes in bovine colon epithelial cell cultures

The metabolic competence of cultured bovine colon epithelial cells was evaluated by determining activities of phase I and II enzymes in colonocytes cultured for different intervals (maximum of 10 days) compared with activities measured in freshly isolated cells. Cytochrome p50 1A1-associated 7-ethox...

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Veröffentlicht in:	Archives of toxicology 2003-11, Vol.77 (11), p.621-629
Hauptverfasser:	BIRKNER, Sascha, WEBER, Susanne, DOHLE, Angelika, SCHMAHL, Günter, BOLT, Hermann Maximilian, FÖLLMANN, Wolfram
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaculture Biological and medical sciences Biomarkers Cattle Cells, Cultured Colon - enzymology Colorectal cancer Culture Media Cytosol - enzymology drug-metabolizing enzymes Enzymes epithelial cells Epithelial Cells - enzymology General aspects. Methods Immunohistochemistry Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Microsomes, Liver - enzymology Mixed Function Oxygenases - biosynthesis Pharmaceutical Preparations - metabolism Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Toxicology Xenobiotics - metabolism
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