Role of Complement-Binding CD21/CD19/CD81 in Enhancing Human B Cell Protection from Fas-Mediated Apoptosis

Defective expression of Fas leads to B cell autoimmunity, indicating the importance of this apoptotic pathway in eliminating autoreactive B cells. However, B cells with anti-self specificities occasionally escape such regulation in individuals with intact Fas, suggesting ways of precluding this apop...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (10), p.5244-5254
Hauptverfasser:	Mongini, Patricia K. A, Jackson, Anna E, Tolani, Sonia, Fattah, Rasem J, Inman, John K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - physiology Adolescent Antibodies, Monoclonal - pharmacology Antigens, CD - metabolism Antigens, CD - physiology Antigens, CD19 - metabolism Antigens, CD19 - physiology Apoptosis - immunology Apoptosis Regulatory Proteins B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism bcl-X Protein Binding Sites - immunology Carrier Proteins - biosynthesis Caspase 8 Caspases - biosynthesis Caspases - metabolism CD40 Antigens - pharmacology CD40 Ligand - pharmacology Cell Survival - immunology Cells, Cultured Child Child, Preschool Complement C3 - metabolism DNA Fragmentation - immunology Fas Ligand Protein fas Receptor - biosynthesis fas Receptor - immunology fas Receptor - metabolism fas Receptor - physiology Humans Intracellular Signaling Peptides and Proteins Ligands Macromolecular Substances Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Membrane Proteins - physiology Nuclear Proteins - biosynthesis Protein Binding - immunology Proto-Oncogene Proteins c-bcl-2 - biosynthesis Receptors, Antigen, B-Cell - metabolism Receptors, Complement 3d - metabolism Receptors, Complement 3d - physiology Tetraspanin 28 TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - biosynthesis
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