Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty
Background: Surgical trauma leads to systemic changes in haemostasis. Haematological changes activated by surgery may become so prominent that changes caused by anaesthesia might be hidden or underestimated. Therefore, we have undertaken a prospective study to compare the behaviour of selected fact...
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| Veröffentlicht in: | Acta anaesthesiologica Scandinavica 2003-11, Vol.47 (10), p.1242-1247 |
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| creator | Özer, E. Çeli̇ker, V. Aypar, Ü. Başgül, E. |
| description | Background: Surgical trauma leads to systemic changes in haemostasis. Haematological changes activated by surgery may become so prominent that changes caused by anaesthesia might be hidden or underestimated. Therefore, we have undertaken a prospective study to compare the behaviour of selected factors involved in the coagulation and fibrinolytic systems.
Methods: Forty healthy adult patients scheduled for otological surgery were enrolled in the study. Upon receiving informed consent, they were randomly assigned to receive either inhalational (IA) or total intravenous anaesthesia (TIVA). Platelet function (PFA100TM), disseminated intravascular coagulopathy (DIC) panel, and generalized d‐dimer (GFC) were studied during certain periods of anaesthesia to identify the changes in haemostasis.
Results: Statistically, no significant change in DIC parameters were encountered between the two groups. No statistical difference was found between the two groups in the measured coagulation parameters, but statistically GFC showed slight activation in the 1st hour of surgical intervention.
Conclusion: Presuming a minimal traumatic effect of surgical procedure on the determined variables, we conclude that different anaesthetic techniques have a negligible effect on platelet activation and fibrinolysis. The clinical relevance of coagulation activation and fibrinolysis during different anaesthetic techniques remains to be investigated. |
| doi_str_mv | 10.1046/j.1399-6576.2003.00234.x |
| format | Article |
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Methods: Forty healthy adult patients scheduled for otological surgery were enrolled in the study. Upon receiving informed consent, they were randomly assigned to receive either inhalational (IA) or total intravenous anaesthesia (TIVA). Platelet function (PFA100TM), disseminated intravascular coagulopathy (DIC) panel, and generalized d‐dimer (GFC) were studied during certain periods of anaesthesia to identify the changes in haemostasis.
Results: Statistically, no significant change in DIC parameters were encountered between the two groups. No statistical difference was found between the two groups in the measured coagulation parameters, but statistically GFC showed slight activation in the 1st hour of surgical intervention.
Conclusion: Presuming a minimal traumatic effect of surgical procedure on the determined variables, we conclude that different anaesthetic techniques have a negligible effect on platelet activation and fibrinolysis. The clinical relevance of coagulation activation and fibrinolysis during different anaesthetic techniques remains to be investigated.</description><identifier>ISSN: 0001-5172</identifier><identifier>EISSN: 1399-6576</identifier><identifier>DOI: 10.1046/j.1399-6576.2003.00234.x</identifier><identifier>PMID: 14616321</identifier><identifier>CODEN: AANEAB</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adult ; Anesthesia ; Anesthesia, Inhalation ; Anesthesia, Intravenous ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Coagulation Tests ; Coagulation ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinolysis ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; GFC ; Hemostasis ; Humans ; inhalational anaesthesia ; Male ; Medical sciences ; PFA 100TM ; Platelet Function Tests ; Prospective Studies ; TIVA ; Tympanoplasty</subject><ispartof>Acta anaesthesiologica Scandinavica, 2003-11, Vol.47 (10), p.1242-1247</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4824-ff75ecd28f0351f44fb1ef24b0e754563fafab3d02102e9dc7e821082b94382b3</citedby><cites>FETCH-LOGICAL-c4824-ff75ecd28f0351f44fb1ef24b0e754563fafab3d02102e9dc7e821082b94382b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1399-6576.2003.00234.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1399-6576.2003.00234.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15280939$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14616321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özer, E.</creatorcontrib><creatorcontrib>Çeli̇ker, V.</creatorcontrib><creatorcontrib>Aypar, Ü.</creatorcontrib><creatorcontrib>Başgül, E.</creatorcontrib><title>Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty</title><title>Acta anaesthesiologica Scandinavica</title><addtitle>Acta Anaesthesiol Scand</addtitle><description>Background: Surgical trauma leads to systemic changes in haemostasis. Haematological changes activated by surgery may become so prominent that changes caused by anaesthesia might be hidden or underestimated. Therefore, we have undertaken a prospective study to compare the behaviour of selected factors involved in the coagulation and fibrinolytic systems.
Methods: Forty healthy adult patients scheduled for otological surgery were enrolled in the study. Upon receiving informed consent, they were randomly assigned to receive either inhalational (IA) or total intravenous anaesthesia (TIVA). Platelet function (PFA100TM), disseminated intravascular coagulopathy (DIC) panel, and generalized d‐dimer (GFC) were studied during certain periods of anaesthesia to identify the changes in haemostasis.
Results: Statistically, no significant change in DIC parameters were encountered between the two groups. No statistical difference was found between the two groups in the measured coagulation parameters, but statistically GFC showed slight activation in the 1st hour of surgical intervention.
Conclusion: Presuming a minimal traumatic effect of surgical procedure on the determined variables, we conclude that different anaesthetic techniques have a negligible effect on platelet activation and fibrinolysis. The clinical relevance of coagulation activation and fibrinolysis during different anaesthetic techniques remains to be investigated.</description><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthesia, Intravenous</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation Tests</subject><subject>Coagulation</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinolysis</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>GFC</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>inhalational anaesthesia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>PFA 100TM</subject><subject>Platelet Function Tests</subject><subject>Prospective Studies</subject><subject>TIVA</subject><subject>Tympanoplasty</subject><issn>0001-5172</issn><issn>1399-6576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2P0zAQhi0EYrsLfwHlArcEf8VJJC6lgt2VKhACtNysSTKmLold7IRt_z0urXavXGyP5nnt8UNIxmjBqFRvtwUTTZOrslIFp1QUlHIhi_0TsnhoPCULSinLS1bxC3IZ4zaVQjbNc3LBpGJKcLYg-taZYUbXYeZNNvkJhsy6KcAfdH6OGbg-1RsYYLLepSY4wDhtMFrIvMs2gKOPE0Qbs34O1v3MpsO4A-d3A8Tp8II8MzBEfHner8j3jx--rW7y9efr29VynXey5jI3piqx63ltqCiZkdK0DA2XLcWqlKUSBgy0oqecUY5N31VYp2PN20aKtIor8uZ07y7433OaUI82djgM4DD9Q1dMKK5UmcD6BHbBxxjQ6F2wI4SDZlQf5eqtPjrUR4f6KFf_k6v3Kfrq_Mbcjtg_Bs82E_D6DEDsYDABXGfjI1fymjaiSdy7E3dvBzz89wB6ufyaDimen-I2Trh_iEP4pVUlqlLffbrW8m5982P1pdLvxV8MrKYN</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Özer, E.</creator><creator>Çeli̇ker, V.</creator><creator>Aypar, Ü.</creator><creator>Başgül, E.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty</title><author>Özer, E. ; Çeli̇ker, V. ; Aypar, Ü. ; Başgül, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4824-ff75ecd28f0351f44fb1ef24b0e754563fafab3d02102e9dc7e821082b94382b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthesia, Intravenous</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation Tests</topic><topic>Coagulation</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinolysis</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>GFC</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>inhalational anaesthesia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>PFA 100TM</topic><topic>Platelet Function Tests</topic><topic>Prospective Studies</topic><topic>TIVA</topic><topic>Tympanoplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özer, E.</creatorcontrib><creatorcontrib>Çeli̇ker, V.</creatorcontrib><creatorcontrib>Aypar, Ü.</creatorcontrib><creatorcontrib>Başgül, E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta anaesthesiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özer, E.</au><au>Çeli̇ker, V.</au><au>Aypar, Ü.</au><au>Başgül, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty</atitle><jtitle>Acta anaesthesiologica Scandinavica</jtitle><addtitle>Acta Anaesthesiol Scand</addtitle><date>2003-11</date><risdate>2003</risdate><volume>47</volume><issue>10</issue><spage>1242</spage><epage>1247</epage><pages>1242-1247</pages><issn>0001-5172</issn><eissn>1399-6576</eissn><coden>AANEAB</coden><abstract>Background: Surgical trauma leads to systemic changes in haemostasis. Haematological changes activated by surgery may become so prominent that changes caused by anaesthesia might be hidden or underestimated. Therefore, we have undertaken a prospective study to compare the behaviour of selected factors involved in the coagulation and fibrinolytic systems.
Methods: Forty healthy adult patients scheduled for otological surgery were enrolled in the study. Upon receiving informed consent, they were randomly assigned to receive either inhalational (IA) or total intravenous anaesthesia (TIVA). Platelet function (PFA100TM), disseminated intravascular coagulopathy (DIC) panel, and generalized d‐dimer (GFC) were studied during certain periods of anaesthesia to identify the changes in haemostasis.
Results: Statistically, no significant change in DIC parameters were encountered between the two groups. No statistical difference was found between the two groups in the measured coagulation parameters, but statistically GFC showed slight activation in the 1st hour of surgical intervention.
Conclusion: Presuming a minimal traumatic effect of surgical procedure on the determined variables, we conclude that different anaesthetic techniques have a negligible effect on platelet activation and fibrinolysis. The clinical relevance of coagulation activation and fibrinolysis during different anaesthetic techniques remains to be investigated.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14616321</pmid><doi>10.1046/j.1399-6576.2003.00234.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anesthesia Anesthesia, Inhalation Anesthesia, Intravenous Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation Tests Coagulation Female Fibrin Fibrinogen Degradation Products - analysis Fibrinolysis General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation GFC Hemostasis Humans inhalational anaesthesia Male Medical sciences PFA 100TM Platelet Function Tests Prospective Studies TIVA Tympanoplasty |
| title | Influence of total intravenous and inhalational anaesthesia on haemostasis during tympanoplasty |
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