Structural characterization, physicochemical properties, and thermal stability of three crystal forms of nifedipine

In this study the single‐crystal X‐ray structure of the solvated species (nifedipine)2 · 1,4‐dioxane is reported for the first time. Included solvent molecules are located in isolated cavities in the crystal, yielding a very stable solvate. Desolvation of this species involves complete disruption of...

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Veröffentlicht in:Journal of pharmaceutical sciences 2003-12, Vol.92 (12), p.2519-2533
Hauptverfasser: Caira, Mino R., Robbertse, Yolande, Bergh, Jacobus J., Song, Mingna, De Villiers, Melgardt M.
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Sprache:eng
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