Investigation of Protein/Carbohydrate Interactions in the Dried State. 1. Calorimetric Studies

Isoperibol calorimetry was used to evaluate protein/carbohydrate interactions after freeze drying. rh‐DNase, rh‐GH, rh‐MetGH, and rh‐IGF‐I were freeze dried with either mannitol, sucrose, trehalose, or dextran at concentrations ranging from 0% to 100% (w/w). Enthalpies of solution for both freeze‐dr...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2002-01, Vol.91 (1), p.206-216
Hauptverfasser:	Souillac, Pierre O., Costantino, Henry R., Middaugh, C.Russell, Rytting, J.Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences calorimetric studies Calorimetry, Differential Scanning - methods Calorimetry, Differential Scanning - statistics & numerical data Carbohydrates - chemistry Dextrans - chemistry dried state Freeze Drying - methods Freeze Drying - statistics & numerical data General pharmacology Humans Mannitol - chemistry Medical sciences Pharmacology. Drug treatments protein/carbohydrate interactions Proteins - chemistry Solutions Sucrose - chemistry Trehalose - chemistry
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