Elevated levels of Rad51 recombination protein in tumor cells

Rad51 is the key enzyme for homologous recombination, an evolutionarily conserved mechanism for the repair of DNA damage and the generation of genetic diversity. Given the observation that many tumors become resistant to radiation therapy and DNA-damaging chemotherapeutics and also that tumor cell p...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002, Vol.62 (1), p.219-225
Hauptverfasser:	RADERSCHALL, Elke, STOUT, Karen, FREIER, Susanne, SUCKOW, Vanessa, SCHWEIGER, Susann, HAAF, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Line, Transformed Chemotherapy DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Gene Amplification Humans Medical sciences Neoplasms - genetics Neoplasms - metabolism Pharmacology. Drug treatments Rad51 Recombinase Recombinant Proteins - biosynthesis Recombinant Proteins - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumor Cells, Cultured
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