FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

Deregulation of apoptosis, the physiological form of cell death, is closely associated with immunological diseases and cancer. Apoptosis is activated either by death receptor-driven or mitochondrial pathways, both of which may provide potential targets for novel anticancer drugs. Although several li...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-11, Vol.63 (21), p.7436-7442
Hauptverfasser:	HASMANN, Max, SCHEMAINDA, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - pharmacology Adenosine Triphosphate - metabolism Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Cell Line, Tumor Enzyme Inhibitors - pharmacology Humans K562 Cells Kinetics Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - pathology Medical sciences Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism NAD - metabolism Niacin - pharmacology Niacinamide - pharmacology Nicotinamide Phosphoribosyltransferase Oxygen Consumption - drug effects Pentosyltransferases - antagonists & inhibitors Pharmacology. Drug treatments Piperidines - pharmacology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!