Microrheology, stress fluctuations, and active behavior of living cells
We report the first measurements of the intrinsic strain fluctuations of living cells using a recently developed tracer correlation technique along with a theoretical framework for interpreting such data in heterogeneous media with nonthermal driving. The fluctuations' spatial and temporal corr...
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| Veröffentlicht in: | Physical review letters 2003-11, Vol.91 (19), p.198101-198101, Article 198101 |
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| container_end_page | 198101 |
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| container_issue | 19 |
| container_start_page | 198101 |
| container_title | Physical review letters |
| container_volume | 91 |
| creator | Lau, A W C Hoffman, B D Davies, A Crocker, J C Lubensky, T C |
| description | We report the first measurements of the intrinsic strain fluctuations of living cells using a recently developed tracer correlation technique along with a theoretical framework for interpreting such data in heterogeneous media with nonthermal driving. The fluctuations' spatial and temporal correlations indicate that the cytoskeleton can be treated as a course-grained continuum with power-law rheology, driven by a spatially random stress tensor field. Combined with recent cell rheology results, our data imply that intracellular stress fluctuations have a nearly 1/omega2 power spectrum, as expected for a continuum with a slowly evolving internal prestress. |
| doi_str_mv | 10.1103/physrevlett.91.198101 |
| format | Article |
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| identifier | ISSN: 0031-9007 |
| ispartof | Physical review letters, 2003-11, Vol.91 (19), p.198101-198101, Article 198101 |
| issn | 0031-9007 1079-7114 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71358265 |
| source | MEDLINE; American Physical Society Journals |
| subjects | Cell Physiological Phenomena Elasticity Mathematical Computing Rheology - methods Stress, Mechanical Viscosity |
| title | Microrheology, stress fluctuations, and active behavior of living cells |
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