p53 mutant mice that display early ageing-associated phenotypes

The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encod...

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Veröffentlicht in:	Nature (London) 2002-01, Vol.415 (6867), p.45-53
Hauptverfasser:	Tyner, Stuart D., Venkatachalam, Sundaresan, Choi, Jene, Jones, Stephen, Ghebranious, Nader, Igelmann, Herbert, Lu, Xiongbin, Soron, Gabrielle, Cooper, Benjamin, Brayton, Cory, Hee Park, Sang, Thompson, Timothy, Karsenty, Gerard, Bradley, Allan, Donehower, Lawrence A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - abnormalities Adipose Tissue - metabolism Adipose Tissue - pathology Ageing, cell death Aging Aging - genetics Aging, Premature - genetics Aging, Premature - metabolism Aging, Premature - pathology Alleles Animals Biological and medical sciences Biological effects Body Weight Bone and Bones - cytology Bone and Bones - metabolism Bone and Bones - pathology Cell physiology Cell Transformation, Neoplastic Cells, Cultured Exons - genetics Female Fundamental and applied biological sciences. Psychology Gene mutations Genes Genes, p53 - genetics Genetic aspects Genetic engineering Hair - abnormalities Hair - growth & development Hair - metabolism Humanities and Social Sciences Longevity - genetics Male Mice Mice, Transgenic Molecular and cellular biology multidisciplinary Mutation Neoplasms - genetics Neoplasms - pathology Organ Size Osteoporosis Osteoporosis - genetics Phenotype Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Science (multidisciplinary) Sequence Deletion - genetics Skin - growth & development Skin - metabolism Skin - pathology Tumor suppressor genes Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Wound Healing
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