Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses

To investigate possible mechanisms behind HIV-1 escape from CTL, we performed detailed longitudinal analysis of Gag (SLYNTVATL)- and RT (ILKEPVHGV)-specific CTL responses and plasma epitope sequences in five individuals. Among those with CTL against consensus epitope sequences, epitope mutations dev...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (10), p.5372-5379
Hauptverfasser:	Jamieson, Beth D, Yang, Otto O, Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Matud, Jose, Kunstman, Kevin, Killian, Scott, Altman, John, Kommander, Kristina, Korber, Bette, Giorgi, Janis, Wolinsky, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - virology Cell Differentiation - genetics Cell Differentiation - immunology Cytotoxicity, Immunologic - genetics Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Evolution, Molecular Gene Products, gag - genetics Gene Products, gag - immunology Gene Products, pol - genetics Gene Products, pol - immunology Genetic Variation - immunology HIV Seropositivity - genetics HIV Seropositivity - immunology HIV Seropositivity - virology HIV-1 - genetics HIV-1 - immunology Humans Interferon-gamma - biosynthesis Lymphocyte Count Male Molecular Sequence Data Mutation Peptide Fragments - genetics Peptide Fragments - immunology Phylogeny Sequence Alignment T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology T-Lymphocytes, Cytotoxic - virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!