Identification and characterization of the murine ortholog (brms1) of breast‐cancer metastasis suppressor 1 (BRMS1)

We have cloned a novel metastasis‐suppressor gene (BRMS1) by differential display, comparing metastatic human breast carcinoma cell line MDA‐MB‐435 to its metastasis‐suppressed human chromosome 11 microcell hybrid. Screening of a murine cDNA library led to the identification of a 1.4 kb cDNA with a...

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Veröffentlicht in:	International journal of cancer 2002-01, Vol.97 (1), p.15-20
Hauptverfasser:	Samant, Rajeev S., Debies, Michael T., Shevde, Lalita A., Verderame, Michael F., Welch, Danny R.
Format:	Artikel
Sprache:	eng
Schlagworte:	66cl4 cells Amino Acid Sequence Animal tumors. Experimental tumors Animals Biological and medical sciences Blotting, Northern breast cancer BRMS1 brms1 gene Chromosomes, Artificial, Bacterial - genetics DNA Primers - chemistry Female human chromosome 11q13 Humans Immunoblotting Lung Neoplasms - prevention & control Lung Neoplasms - secondary Mammary Neoplasms, Experimental - prevention & control Mammary Neoplasms, Experimental - secondary Medical sciences metastasis‐suppressor gene Mice Mice, Inbred BALB C Molecular Sequence Data murine ortholog Neoplasm Proteins Proteins - chemistry Proteins - isolation & purification Proteins - physiology Repressor Proteins RNA, Messenger - metabolism Sequence Homology, Amino Acid Spontaneous animal tumors syntenic Transfection Tumors
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