Validation of the behavioural activity rating scale (BARS)™: a novel measure of activity in agitated patients
We report psychometric results of the Behavioural Activity Rating Scale (BARS™) using data from three Phase III clinical trials of intramuscular ziprasidone in acutely agitated patients with psychosis (Studies 1 and 2) or in stable psychotic patients (Study 3). Convergent validity and divergent vali...
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| Veröffentlicht in: | Journal of psychiatric research 2002-03, Vol.36 (2), p.87-95 |
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| creator | Swift, R.H Harrigan, E.P Cappelleri, J.C Kramer, D Chandler, L.P |
| description | We report psychometric results of the Behavioural Activity Rating Scale (BARS™) using data from three Phase III clinical trials of intramuscular ziprasidone in acutely agitated patients with psychosis (Studies 1 and 2) or in stable psychotic patients (Study 3). Convergent validity and divergent validity were assessed with baseline data from Studies 1 and 2 in subjects with acute agitation. To investigate convergent validity, we sought Pearson and Spearman correlation of BARS™ scores with scores on the Clinical Global Impression of Severity (CGI-S) Scale and a predefined cluster of agitation-related items from the Positive and Negative Syndrome Scale (PANSS). For divergent validity, we sought Pearson and Spearman correlation between BARS™ scores and a predefined cluster of PANSS items measuring negative symptoms. Discriminant validity was investigated with the help of subjects with moderate psychopathology (Study 3). Wilcoxon rank-sum and two-sample
t tests determined whether mean (or median) BARS™ scores differed between subjects with acute agitation (Studies 1 and 2) and moderate psychopathology (Study 3). Responsiveness to treatment effect and rater reliability were also evaluated. In Study 2, Pearson correlation coefficients of BARS™ scores with PANSS agitation items and CGI-S were moderate (
convergent validity) and statistically significant (
P |
| doi_str_mv | 10.1016/S0022-3956(01)00052-8 |
| format | Article |
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t tests determined whether mean (or median) BARS™ scores differed between subjects with acute agitation (Studies 1 and 2) and moderate psychopathology (Study 3). Responsiveness to treatment effect and rater reliability were also evaluated. In Study 2, Pearson correlation coefficients of BARS™ scores with PANSS agitation items and CGI-S were moderate (
convergent validity) and statistically significant (
P<0.005). The correlation between BARS™ scores and PANSS negative component scores was low (
divergent validity). Treatment effect size was larger for BARS™ than for PANSS agitation items and CGI-S (
responsive to treatment differences). Virtually perfect inter- and intra-rater reliability was achieved. Study 1 produced similar results. BARS™ showed psychometrically valid properties for measurement of behavioral activity in acutely agitated patients with psychosis.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/S0022-3956(01)00052-8</identifier><identifier>PMID: 11777497</identifier><identifier>CODEN: JPYRA3</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Behavioural Activity Rating Scale ; Biological and medical sciences ; Cluster Analysis ; Dopamine Antagonists - therapeutic use ; Humans ; Medical sciences ; Piperazines - therapeutic use ; Psychology. Psychoanalysis. Psychiatry ; Psychometric validation ; Psychometrics ; Psychometrics. Diagnostic aid systems ; Psychomotor Agitation - diagnosis ; Psychomotor Agitation - drug therapy ; Psychomotor Agitation - psychology ; Psychopathology. Psychiatry ; Reproducibility of Results ; Severity of Illness Index ; Surveys and Questionnaires ; Techniques and methods ; Thiazoles - therapeutic use ; Ziprasidone</subject><ispartof>Journal of psychiatric research, 2002-03, Vol.36 (2), p.87-95</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-269e1e772407615fa573f6553af6e17f19382d56fb8e56cecbde18b9e987a7213</citedby><cites>FETCH-LOGICAL-c391t-269e1e772407615fa573f6553af6e17f19382d56fb8e56cecbde18b9e987a7213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022395601000528$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13464887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11777497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swift, R.H</creatorcontrib><creatorcontrib>Harrigan, E.P</creatorcontrib><creatorcontrib>Cappelleri, J.C</creatorcontrib><creatorcontrib>Kramer, D</creatorcontrib><creatorcontrib>Chandler, L.P</creatorcontrib><title>Validation of the behavioural activity rating scale (BARS)™: a novel measure of activity in agitated patients</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>We report psychometric results of the Behavioural Activity Rating Scale (BARS™) using data from three Phase III clinical trials of intramuscular ziprasidone in acutely agitated patients with psychosis (Studies 1 and 2) or in stable psychotic patients (Study 3). Convergent validity and divergent validity were assessed with baseline data from Studies 1 and 2 in subjects with acute agitation. To investigate convergent validity, we sought Pearson and Spearman correlation of BARS™ scores with scores on the Clinical Global Impression of Severity (CGI-S) Scale and a predefined cluster of agitation-related items from the Positive and Negative Syndrome Scale (PANSS). For divergent validity, we sought Pearson and Spearman correlation between BARS™ scores and a predefined cluster of PANSS items measuring negative symptoms. Discriminant validity was investigated with the help of subjects with moderate psychopathology (Study 3). Wilcoxon rank-sum and two-sample
t tests determined whether mean (or median) BARS™ scores differed between subjects with acute agitation (Studies 1 and 2) and moderate psychopathology (Study 3). Responsiveness to treatment effect and rater reliability were also evaluated. In Study 2, Pearson correlation coefficients of BARS™ scores with PANSS agitation items and CGI-S were moderate (
convergent validity) and statistically significant (
P<0.005). The correlation between BARS™ scores and PANSS negative component scores was low (
divergent validity). Treatment effect size was larger for BARS™ than for PANSS agitation items and CGI-S (
responsive to treatment differences). Virtually perfect inter- and intra-rater reliability was achieved. Study 1 produced similar results. BARS™ showed psychometrically valid properties for measurement of behavioral activity in acutely agitated patients with psychosis.</description><subject>Behavioural Activity Rating Scale</subject><subject>Biological and medical sciences</subject><subject>Cluster Analysis</subject><subject>Dopamine Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Piperazines - therapeutic use</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometric validation</subject><subject>Psychometrics</subject><subject>Psychometrics. Diagnostic aid systems</subject><subject>Psychomotor Agitation - diagnosis</subject><subject>Psychomotor Agitation - drug therapy</subject><subject>Psychomotor Agitation - psychology</subject><subject>Psychopathology. Psychiatry</subject><subject>Reproducibility of Results</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Techniques and methods</subject><subject>Thiazoles - therapeutic use</subject><subject>Ziprasidone</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu1TAQhi0EoqeFRwB5A2oXAU8cX8IGlYqbVAmJAlvLccatUU5yajtH6r5PwqPxJDg9R-2S1Wy-_5-Zj5AXwN4AA_n2grG6rngr5DGDE8aYqCv9iKxAq7YCrtrHZHWPHJDDlH4XSNXQPCUHAEqpplUrMv2yQ-htDtNIJ0_zFdIOr-w2THO0A7Uuh23INzQWZLykydkB6fGH0-8XJ39v_7yjlo7TFge6RpvmiEvHfSaM1F6GbDP2dFPyOOb0jDzxdkj4fD-PyM9PH3-cfanOv33-enZ6XjneQq5q2SKgUnXDlAThrVDcSyG49RJBeWi5rnshfadRSIeu6xF012KrlS1P8iPyete7idP1jCmbdUgOh8GOOM3JKOBCSqgLKHagi1NKEb3ZxLC28cYAM4tpc2faLBoNA3Nn2uiSe7lfMHdr7B9Se7UFeLUH7GLNRzu6kB443shG64V7v-Ow6NgGjCa5osphHyK6bPop_OeUf3s9m3M</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Swift, R.H</creator><creator>Harrigan, E.P</creator><creator>Cappelleri, J.C</creator><creator>Kramer, D</creator><creator>Chandler, L.P</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Validation of the behavioural activity rating scale (BARS)™: a novel measure of activity in agitated patients</title><author>Swift, R.H ; Harrigan, E.P ; Cappelleri, J.C ; Kramer, D ; Chandler, L.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-269e1e772407615fa573f6553af6e17f19382d56fb8e56cecbde18b9e987a7213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Behavioural Activity Rating Scale</topic><topic>Biological and medical sciences</topic><topic>Cluster Analysis</topic><topic>Dopamine Antagonists - therapeutic use</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Piperazines - therapeutic use</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometric validation</topic><topic>Psychometrics</topic><topic>Psychometrics. Diagnostic aid systems</topic><topic>Psychomotor Agitation - diagnosis</topic><topic>Psychomotor Agitation - drug therapy</topic><topic>Psychomotor Agitation - psychology</topic><topic>Psychopathology. Psychiatry</topic><topic>Reproducibility of Results</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Techniques and methods</topic><topic>Thiazoles - therapeutic use</topic><topic>Ziprasidone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swift, R.H</creatorcontrib><creatorcontrib>Harrigan, E.P</creatorcontrib><creatorcontrib>Cappelleri, J.C</creatorcontrib><creatorcontrib>Kramer, D</creatorcontrib><creatorcontrib>Chandler, L.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swift, R.H</au><au>Harrigan, E.P</au><au>Cappelleri, J.C</au><au>Kramer, D</au><au>Chandler, L.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the behavioural activity rating scale (BARS)™: a novel measure of activity in agitated patients</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>36</volume><issue>2</issue><spage>87</spage><epage>95</epage><pages>87-95</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><coden>JPYRA3</coden><abstract>We report psychometric results of the Behavioural Activity Rating Scale (BARS™) using data from three Phase III clinical trials of intramuscular ziprasidone in acutely agitated patients with psychosis (Studies 1 and 2) or in stable psychotic patients (Study 3). Convergent validity and divergent validity were assessed with baseline data from Studies 1 and 2 in subjects with acute agitation. To investigate convergent validity, we sought Pearson and Spearman correlation of BARS™ scores with scores on the Clinical Global Impression of Severity (CGI-S) Scale and a predefined cluster of agitation-related items from the Positive and Negative Syndrome Scale (PANSS). For divergent validity, we sought Pearson and Spearman correlation between BARS™ scores and a predefined cluster of PANSS items measuring negative symptoms. Discriminant validity was investigated with the help of subjects with moderate psychopathology (Study 3). Wilcoxon rank-sum and two-sample
t tests determined whether mean (or median) BARS™ scores differed between subjects with acute agitation (Studies 1 and 2) and moderate psychopathology (Study 3). Responsiveness to treatment effect and rater reliability were also evaluated. In Study 2, Pearson correlation coefficients of BARS™ scores with PANSS agitation items and CGI-S were moderate (
convergent validity) and statistically significant (
P<0.005). The correlation between BARS™ scores and PANSS negative component scores was low (
divergent validity). Treatment effect size was larger for BARS™ than for PANSS agitation items and CGI-S (
responsive to treatment differences). Virtually perfect inter- and intra-rater reliability was achieved. Study 1 produced similar results. BARS™ showed psychometrically valid properties for measurement of behavioral activity in acutely agitated patients with psychosis.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11777497</pmid><doi>10.1016/S0022-3956(01)00052-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Behavioural Activity Rating Scale Biological and medical sciences Cluster Analysis Dopamine Antagonists - therapeutic use Humans Medical sciences Piperazines - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychometric validation Psychometrics Psychometrics. Diagnostic aid systems Psychomotor Agitation - diagnosis Psychomotor Agitation - drug therapy Psychomotor Agitation - psychology Psychopathology. Psychiatry Reproducibility of Results Severity of Illness Index Surveys and Questionnaires Techniques and methods Thiazoles - therapeutic use Ziprasidone |
| title | Validation of the behavioural activity rating scale (BARS)™: a novel measure of activity in agitated patients |
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