Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha

Osteoclasts are derived from hemopoietic stem cells and play critical roles in bone resorption and remodeling. Multinucleated osteoclasts are attached tightly to bone matrix, whereas precursor cells with the potential to differentiate into osteoclasts in culture are widely distributed. In this study...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-11, Vol.171 (10), p.5130-5139
Hauptverfasser:	Hayashi, Shin-Ichi, Yamada, Takayuki, Tsuneto, Motokazu, Yamane, Toshiyuki, Takahashi, Masayuki, Shultz, Leonard D, Yamazaki, Hidetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascitic Fluid - cytology Ascitic Fluid - immunology Ascitic Fluid - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Carrier Proteins - pharmacology Cell Differentiation - immunology Cell Line Cells, Cultured Clone Cells Glycoproteins - metabolism Growth Inhibitors - pharmacology Immune Tolerance - immunology Injections, Intravenous Ligands Lipopolysaccharides - pharmacology Macrophage Colony-Stimulating Factor - metabolism Macrophage Colony-Stimulating Factor - pharmacology Macrophages - cytology Macrophages - immunology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - metabolism Membrane Glycoproteins - pharmacology Membrane Glycoproteins - physiology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - metabolism Osteoclasts - cytology Osteoclasts - immunology Osteoclasts - metabolism Osteopetrosis - genetics Osteopetrosis - pathology Osteoprotegerin RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Tumor Necrosis Factor Signal Transduction - immunology Spleen - cytology Spleen - immunology Spleen - metabolism Stem Cells - cytology Stem Cells - immunology Stem Cells - metabolism Stromal Cells - cytology Stromal Cells - immunology Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Tumor Necrosis Factor-alpha - physiology
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