Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche
Identification, maintenance, and expansion of stem cells for subsequent transplantation has become a new strategy for treating many diseases in most medical subspecialties. The stem cells of the corneal epithelium are located in the limbal basal layer and are the ultimate source for constant corneal...
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| Veröffentlicht in: | Survey of ophthalmology 2003-11, Vol.48 (6), p.631-646 |
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| creator | Grueterich, Martin Espana, Edgar M. Tseng, Scheffer C.G. |
| description | Identification, maintenance, and expansion of stem cells for subsequent transplantation has become a new strategy for treating many diseases in most medical subspecialties. The stem cells of the corneal epithelium are located in the limbal basal layer and are the ultimate source for constant corneal epithelial renewal. Like those in other tissues, limbal stem cells are supported by a unique stromal microenvironment called the
stem cell niche, which consists of certain extracellular matrix components, cell membrane-associated molecules, and cytokine dialogues. Destructive loss of limbal stem cells or dysfunction of their stromal environment renders many corneas with a clinical entity called limbal stem cell deficiency, which is characterized by variable extents of conjunctival ingrowth depending on the severity of limbal damage. A new strategy of treating limbal stem cell deficiency is to transplant a bio-engineered graft by expanding limbal epithelial stem cells ex vivo on amniotic membrane. This review summarizes the published literature data collectively explaining how amniotic membrane is an ideal biological substrate that can help maintain and support the expansion of limbal epithelial stem cells. |
| doi_str_mv | 10.1016/j.survophthal.2003.08.003 |
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stem cell niche, which consists of certain extracellular matrix components, cell membrane-associated molecules, and cytokine dialogues. Destructive loss of limbal stem cells or dysfunction of their stromal environment renders many corneas with a clinical entity called limbal stem cell deficiency, which is characterized by variable extents of conjunctival ingrowth depending on the severity of limbal damage. A new strategy of treating limbal stem cell deficiency is to transplant a bio-engineered graft by expanding limbal epithelial stem cells ex vivo on amniotic membrane. This review summarizes the published literature data collectively explaining how amniotic membrane is an ideal biological substrate that can help maintain and support the expansion of limbal epithelial stem cells.</description><identifier>ISSN: 0039-6257</identifier><identifier>EISSN: 1879-3304</identifier><identifier>DOI: 10.1016/j.survophthal.2003.08.003</identifier><identifier>PMID: 14609709</identifier><identifier>CODEN: SUOPAD</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>allograft ; Amnion ; amniotic membrane ; autograft ; Biological and medical sciences ; Biomarkers - analysis ; Cell Culture Techniques - methods ; Cell Differentiation ; Cell Division ; Corneal Diseases - surgery ; differentiation ; Epithelial Cells - cytology ; Epithelial Cells - physiology ; epithelium ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Humans ; limbal stem cell deficiency ; limbus ; Limbus Corneae - cytology ; Medical sciences ; stem cell ; Stem Cell Transplantation ; Stem Cells - cytology ; Stem Cells - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Vertebrates: nervous system and sense organs</subject><ispartof>Survey of ophthalmology, 2003-11, Vol.48 (6), p.631-646</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-29a13116fc602f87e800f33c3bc6ceed0efcd48d6992ed8ab009b376a621f5333</citedby><cites>FETCH-LOGICAL-c469t-29a13116fc602f87e800f33c3bc6ceed0efcd48d6992ed8ab009b376a621f5333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.survophthal.2003.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15303743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14609709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grueterich, Martin</creatorcontrib><creatorcontrib>Espana, Edgar M.</creatorcontrib><creatorcontrib>Tseng, Scheffer C.G.</creatorcontrib><title>Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche</title><title>Survey of ophthalmology</title><addtitle>Surv Ophthalmol</addtitle><description>Identification, maintenance, and expansion of stem cells for subsequent transplantation has become a new strategy for treating many diseases in most medical subspecialties. The stem cells of the corneal epithelium are located in the limbal basal layer and are the ultimate source for constant corneal epithelial renewal. Like those in other tissues, limbal stem cells are supported by a unique stromal microenvironment called the
stem cell niche, which consists of certain extracellular matrix components, cell membrane-associated molecules, and cytokine dialogues. Destructive loss of limbal stem cells or dysfunction of their stromal environment renders many corneas with a clinical entity called limbal stem cell deficiency, which is characterized by variable extents of conjunctival ingrowth depending on the severity of limbal damage. A new strategy of treating limbal stem cell deficiency is to transplant a bio-engineered graft by expanding limbal epithelial stem cells ex vivo on amniotic membrane. This review summarizes the published literature data collectively explaining how amniotic membrane is an ideal biological substrate that can help maintain and support the expansion of limbal epithelial stem cells.</description><subject>allograft</subject><subject>Amnion</subject><subject>amniotic membrane</subject><subject>autograft</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Cell Culture Techniques - methods</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Corneal Diseases - surgery</subject><subject>differentiation</subject><subject>Epithelial Cells - cytology</subject><subject>Epithelial Cells - physiology</subject><subject>epithelium</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>limbal stem cell deficiency</subject><subject>limbus</subject><subject>Limbus Corneae - cytology</subject><subject>Medical sciences</subject><subject>stem cell</subject><subject>Stem Cell Transplantation</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0039-6257</issn><issn>1879-3304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMGO0zAQhi0EYrsLr4DMAW4J4zh1Ym6oWliklbjA2XKcMXWVxMGTRrtvj6tWKkdO_8j6ZvzrY-y9gFKAUJ8OJR3TGuf9srdDWQHIEtoyxwu2EW2jCymhfsk2-UUXqto2N-yW6AAAtdTNa3YjagW6Ab1h9v6Jr2GNHJ9mO1GIE4-eD2Hs7MBxDsseh5BHWnDkDoeBPnM7TiEuwfERxy7ZCTlhWsP0m1vi9oryKbg9vmGvvB0I317yjv36ev9z91A8_vj2ffflsXC10ktRaSukEMo7BZVvG2wBvJROdk45xB7Qu75ue6V1hX1rOwDdyUZZVQm_lVLesY_nu3OKf45IixkDnWrkgvFIphFyq6q2zqA-gy5FooTezCmMNj0bAebk1xzMP37Nya-B1uTIu-8unxy7Efvr5kVoBj5cAEvODj7rcYGu3FaCbOrTod2Zw6xkDZgMuYCTwz4kdIvpY_iPOn8Bx7GgZw</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Grueterich, Martin</creator><creator>Espana, Edgar M.</creator><creator>Tseng, Scheffer C.G.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche</title><author>Grueterich, Martin ; Espana, Edgar M. ; Tseng, Scheffer C.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-29a13116fc602f87e800f33c3bc6ceed0efcd48d6992ed8ab009b376a621f5333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>allograft</topic><topic>Amnion</topic><topic>amniotic membrane</topic><topic>autograft</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Cell Culture Techniques - methods</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Corneal Diseases - surgery</topic><topic>differentiation</topic><topic>Epithelial Cells - cytology</topic><topic>Epithelial Cells - physiology</topic><topic>epithelium</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>limbal stem cell deficiency</topic><topic>limbus</topic><topic>Limbus Corneae - cytology</topic><topic>Medical sciences</topic><topic>stem cell</topic><topic>Stem Cell Transplantation</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grueterich, Martin</creatorcontrib><creatorcontrib>Espana, Edgar M.</creatorcontrib><creatorcontrib>Tseng, Scheffer C.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Survey of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grueterich, Martin</au><au>Espana, Edgar M.</au><au>Tseng, Scheffer C.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche</atitle><jtitle>Survey of ophthalmology</jtitle><addtitle>Surv Ophthalmol</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>48</volume><issue>6</issue><spage>631</spage><epage>646</epage><pages>631-646</pages><issn>0039-6257</issn><eissn>1879-3304</eissn><coden>SUOPAD</coden><abstract>Identification, maintenance, and expansion of stem cells for subsequent transplantation has become a new strategy for treating many diseases in most medical subspecialties. The stem cells of the corneal epithelium are located in the limbal basal layer and are the ultimate source for constant corneal epithelial renewal. Like those in other tissues, limbal stem cells are supported by a unique stromal microenvironment called the
stem cell niche, which consists of certain extracellular matrix components, cell membrane-associated molecules, and cytokine dialogues. Destructive loss of limbal stem cells or dysfunction of their stromal environment renders many corneas with a clinical entity called limbal stem cell deficiency, which is characterized by variable extents of conjunctival ingrowth depending on the severity of limbal damage. A new strategy of treating limbal stem cell deficiency is to transplant a bio-engineered graft by expanding limbal epithelial stem cells ex vivo on amniotic membrane. This review summarizes the published literature data collectively explaining how amniotic membrane is an ideal biological substrate that can help maintain and support the expansion of limbal epithelial stem cells.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14609709</pmid><doi>10.1016/j.survophthal.2003.08.003</doi><tpages>16</tpages></addata></record> |
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| subjects | allograft Amnion amniotic membrane autograft Biological and medical sciences Biomarkers - analysis Cell Culture Techniques - methods Cell Differentiation Cell Division Corneal Diseases - surgery differentiation Epithelial Cells - cytology Epithelial Cells - physiology epithelium Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans limbal stem cell deficiency limbus Limbus Corneae - cytology Medical sciences stem cell Stem Cell Transplantation Stem Cells - cytology Stem Cells - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Vertebrates: nervous system and sense organs |
| title | Ex vivo expansion of limbal epithelial stem cells: amniotic membrane serving as a stem cell niche |
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