Pathomorphological Pattern of Paravertebral Muscles of Rabbits After Long-term Experimental Electrostimulation
The objective of this study was to identify the histopathological features of paravertebral muscles after long-term Lateral Electrical Surface Stimulation (LESS). LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2003, Vol.199 (9), p.613-618 |
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| creator | Szarek, Józef Kowalski, Ireneusz M. van Dam, Floris Zarzycki, Daniel Pawlicki, Roman Fabczak, Jacek |
| description | The objective of this study was to identify the histopathological features of paravertebral muscles after long-term Lateral Electrical Surface Stimulation (LESS).
LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect on the mental state of treated patients, as well as functional disturbances of organs, endocrine glands, and muscle metabolism.
The experiment was performed on rabbits (aged 3.5 months), (n = 5 in treated, n = 5 in non-treated group). Stimulation was performed using electrical stimulator SCOL-2. The rabbits were stimulated with the traditional long-term lateral electrical surface stimulation (LESS) method as in clinical applications for children and adolescents.
After microscopic examination, atrophy of fibers and cross striation of paravertebral muscles were seen, as well as degenerative lesions, necrosis, and hyperemia. Furthermore, proliferation of nuclei and infiltration of monocytogenic phagocytes mononuclear cells were observed, as well as a wide differentiation of glycosoaminoglycanes in muscle fibers on the stimulated side. However, within the tissue undergoing regression, this resulted in a clear decrease in glycosoaminoglycane levels.
The observed lesions may indicate that the damage to the neuromuscular system is an effect of long-term LESSapplication. Thus, standard LESStherapy may deepen idiopathic scoliosis. |
| doi_str_mv | 10.1078/0344-0338-00469 |
| format | Article |
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LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect on the mental state of treated patients, as well as functional disturbances of organs, endocrine glands, and muscle metabolism.
The experiment was performed on rabbits (aged 3.5 months), (n = 5 in treated, n = 5 in non-treated group). Stimulation was performed using electrical stimulator SCOL-2. The rabbits were stimulated with the traditional long-term lateral electrical surface stimulation (LESS) method as in clinical applications for children and adolescents.
After microscopic examination, atrophy of fibers and cross striation of paravertebral muscles were seen, as well as degenerative lesions, necrosis, and hyperemia. Furthermore, proliferation of nuclei and infiltration of monocytogenic phagocytes mononuclear cells were observed, as well as a wide differentiation of glycosoaminoglycanes in muscle fibers on the stimulated side. However, within the tissue undergoing regression, this resulted in a clear decrease in glycosoaminoglycane levels.
The observed lesions may indicate that the damage to the neuromuscular system is an effect of long-term LESSapplication. Thus, standard LESStherapy may deepen idiopathic scoliosis.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1078/0344-0338-00469</identifier><identifier>PMID: 14621197</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Electric Injuries - etiology ; Electric Stimulation - adverse effects ; Electric Stimulation Therapy ; Lateral Electrical Surface Stimulation (LESS) ; Male ; Muscle Fibers, Skeletal ; Muscle, Skeletal - injuries ; Muscle, Skeletal - pathology ; Muscles ; Rabbits ; Scoliosis ; Scoliosis - therapy</subject><ispartof>Pathology, research and practice, 2003, Vol.199 (9), p.613-618</ispartof><rights>2003 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-4328a84488f4c7c274464659df54fc145308cfe8ee6f15d375dcd38bc1aa5e2d3</citedby><cites>FETCH-LOGICAL-c370t-4328a84488f4c7c274464659df54fc145308cfe8ee6f15d375dcd38bc1aa5e2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033804704677$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14621197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szarek, Józef</creatorcontrib><creatorcontrib>Kowalski, Ireneusz M.</creatorcontrib><creatorcontrib>van Dam, Floris</creatorcontrib><creatorcontrib>Zarzycki, Daniel</creatorcontrib><creatorcontrib>Pawlicki, Roman</creatorcontrib><creatorcontrib>Fabczak, Jacek</creatorcontrib><title>Pathomorphological Pattern of Paravertebral Muscles of Rabbits After Long-term Experimental Electrostimulation</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>The objective of this study was to identify the histopathological features of paravertebral muscles after long-term Lateral Electrical Surface Stimulation (LESS).
LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect on the mental state of treated patients, as well as functional disturbances of organs, endocrine glands, and muscle metabolism.
The experiment was performed on rabbits (aged 3.5 months), (n = 5 in treated, n = 5 in non-treated group). Stimulation was performed using electrical stimulator SCOL-2. The rabbits were stimulated with the traditional long-term lateral electrical surface stimulation (LESS) method as in clinical applications for children and adolescents.
After microscopic examination, atrophy of fibers and cross striation of paravertebral muscles were seen, as well as degenerative lesions, necrosis, and hyperemia. Furthermore, proliferation of nuclei and infiltration of monocytogenic phagocytes mononuclear cells were observed, as well as a wide differentiation of glycosoaminoglycanes in muscle fibers on the stimulated side. However, within the tissue undergoing regression, this resulted in a clear decrease in glycosoaminoglycane levels.
The observed lesions may indicate that the damage to the neuromuscular system is an effect of long-term LESSapplication. Thus, standard LESStherapy may deepen idiopathic scoliosis.</description><subject>Animals</subject><subject>Electric Injuries - etiology</subject><subject>Electric Stimulation - adverse effects</subject><subject>Electric Stimulation Therapy</subject><subject>Lateral Electrical Surface Stimulation (LESS)</subject><subject>Male</subject><subject>Muscle Fibers, Skeletal</subject><subject>Muscle, Skeletal - injuries</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Rabbits</subject><subject>Scoliosis</subject><subject>Scoliosis - therapy</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUFv3CAQhVGVqtkkPecWWTn05gYMGHyMok0baatWVXNGGA8JkW02gKP233e2u2qlSD0x8D6eZt4Qcs7oR0aVvqJciJpyrmtKRdu9ISvWMry0nB2R1V_1mJzk_EQpVVSwd-SYibZhrFMrMn-z5TFOMW0f4xgfgrNjhU8F0lxFj2WyL5AK9AmFL0t2I-Sd8N32fSi5uvaIVps4P9RYTNX65xZSmGAuyK9HcCXFXMK0jLaEOJ-Rt96OGd4fzlNyf7v-cfO53nz9dHdzvakdV7TUgjfaaiG09sIp1yghWtHKbvBSeMeE5FQ7Dxqg9UwOXMnBDVz3jlkroRn4Kfmw992m-LxALmYK2cE42hniko1iXErVtQhevgKf4pJm7M00VMqGYkoIXe0hh8PkBN5scUabfhlGzW4PZpe02SVt_uwBf1wcbJd-guEffwgegW4PAKbwEiCZ7ALMDoaQMDQzxPBf89_gc5Zi</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Szarek, Józef</creator><creator>Kowalski, Ireneusz M.</creator><creator>van Dam, Floris</creator><creator>Zarzycki, Daniel</creator><creator>Pawlicki, Roman</creator><creator>Fabczak, Jacek</creator><general>Elsevier GmbH</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Pathomorphological Pattern of Paravertebral Muscles of Rabbits After Long-term Experimental Electrostimulation</title><author>Szarek, Józef ; Kowalski, Ireneusz M. ; van Dam, Floris ; Zarzycki, Daniel ; Pawlicki, Roman ; Fabczak, Jacek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4328a84488f4c7c274464659df54fc145308cfe8ee6f15d375dcd38bc1aa5e2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Electric Injuries - etiology</topic><topic>Electric Stimulation - adverse effects</topic><topic>Electric Stimulation Therapy</topic><topic>Lateral Electrical Surface Stimulation (LESS)</topic><topic>Male</topic><topic>Muscle Fibers, Skeletal</topic><topic>Muscle, Skeletal - injuries</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscles</topic><topic>Rabbits</topic><topic>Scoliosis</topic><topic>Scoliosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szarek, Józef</creatorcontrib><creatorcontrib>Kowalski, Ireneusz M.</creatorcontrib><creatorcontrib>van Dam, Floris</creatorcontrib><creatorcontrib>Zarzycki, Daniel</creatorcontrib><creatorcontrib>Pawlicki, Roman</creatorcontrib><creatorcontrib>Fabczak, Jacek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szarek, Józef</au><au>Kowalski, Ireneusz M.</au><au>van Dam, Floris</au><au>Zarzycki, Daniel</au><au>Pawlicki, Roman</au><au>Fabczak, Jacek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathomorphological Pattern of Paravertebral Muscles of Rabbits After Long-term Experimental Electrostimulation</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2003</date><risdate>2003</risdate><volume>199</volume><issue>9</issue><spage>613</spage><epage>618</epage><pages>613-618</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>The objective of this study was to identify the histopathological features of paravertebral muscles after long-term Lateral Electrical Surface Stimulation (LESS).
LESS has been applied for the treatment of idiopathic scoliosis in children and adolescents. Former studies reported the negative effect on the mental state of treated patients, as well as functional disturbances of organs, endocrine glands, and muscle metabolism.
The experiment was performed on rabbits (aged 3.5 months), (n = 5 in treated, n = 5 in non-treated group). Stimulation was performed using electrical stimulator SCOL-2. The rabbits were stimulated with the traditional long-term lateral electrical surface stimulation (LESS) method as in clinical applications for children and adolescents.
After microscopic examination, atrophy of fibers and cross striation of paravertebral muscles were seen, as well as degenerative lesions, necrosis, and hyperemia. Furthermore, proliferation of nuclei and infiltration of monocytogenic phagocytes mononuclear cells were observed, as well as a wide differentiation of glycosoaminoglycanes in muscle fibers on the stimulated side. However, within the tissue undergoing regression, this resulted in a clear decrease in glycosoaminoglycane levels.
The observed lesions may indicate that the damage to the neuromuscular system is an effect of long-term LESSapplication. Thus, standard LESStherapy may deepen idiopathic scoliosis.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>14621197</pmid><doi>10.1078/0344-0338-00469</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 2003, Vol.199 (9), p.613-618 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Electric Injuries - etiology Electric Stimulation - adverse effects Electric Stimulation Therapy Lateral Electrical Surface Stimulation (LESS) Male Muscle Fibers, Skeletal Muscle, Skeletal - injuries Muscle, Skeletal - pathology Muscles Rabbits Scoliosis Scoliosis - therapy |
| title | Pathomorphological Pattern of Paravertebral Muscles of Rabbits After Long-term Experimental Electrostimulation |
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