The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile

Nitric oxide (NO) plays a protective role during atherogenesis. In the endothelium, NO is synthesised by the constitutive NO synthase (ecNOS). We analysed the relation of the ecNOS Glu(298)Asp and 4a/b gene polymorphisms to coronary artery disease (CAD) and myocardial infarction (MI) in a population...

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Veröffentlicht in:	Atherosclerosis 2002-01, Vol.160 (1), p.167-175
Hauptverfasser:	Gardemann, Andreas, Lohre, Jana, Cayci, Sevim, Katz, Norbert, Tillmanns, Harald, Haberbosch, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Biomarkers - blood Body Mass Index Coronary Artery Disease - complications Coronary Artery Disease - genetics Coronary Disease - complications Coronary Disease - genetics Gene Frequency - genetics Genetic Variation - genetics Genotype Germany - epidemiology Humans Male Mutation, Missense - genetics Myocardial Infarction - complications Myocardial Infarction - genetics Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Point Mutation Polymorphism, Genetic - genetics Risk Factors Severity of Illness Index
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