EP2 and EP4 prostanoid receptor signaling
The EP(2) and EP(4) prostanoid receptors are two of the four subtypes of receptors for prostaglandin E(2) (PGE(2)). They are in the family of G-protein coupled receptors and both receptors were initially characterized as coupling to Gs and increasing intracellular cAMP formation. Recently, however,...
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| Veröffentlicht in: | Life sciences (1973) 2003-12, Vol.74 (2-3), p.143-153 |
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| container_title | Life sciences (1973) |
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| creator | Regan, John W |
| description | The EP(2) and EP(4) prostanoid receptors are two of the four subtypes of receptors for prostaglandin E(2) (PGE(2)). They are in the family of G-protein coupled receptors and both receptors were initially characterized as coupling to Gs and increasing intracellular cAMP formation. Recently, however, we have shown that both receptors can stimulate T-cell factor (Tcf) mediated transcriptional activity. The EP(2) receptor does this primarily through cAMP-dependent protein kinase (PKA), whereas the EP(4) utilizes phosphatidylinositol 3-kinase (PI3K) as well as PKA. In addition, we have shown that the EP(4) receptor, but not the EP(2), can activate the extracellular signal-regulated kinases (ERKs) 1 and 2 by way of PI3K leading to the induction of early growth response factor-1 (EGR-1), a transcription factor traditionally associated with wound healing. This induction of EGR-1 expression has significant implications concerning the potential role of PGE(2) in cancer and inflammatory disorders. |
| doi_str_mv | 10.1016/j.lfs.2003.09.031 |
| format | Article |
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This induction of EGR-1 expression has significant implications concerning the potential role of PGE(2) in cancer and inflammatory disorders.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>Receptors, Prostaglandin E - physiology</subject><subject>Receptors, Prostaglandin E, EP2 Subtype</subject><subject>Receptors, Prostaglandin E, EP4 Subtype</subject><subject>Second Messenger Systems - genetics</subject><subject>Second Messenger Systems - physiology</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><issn>0024-3205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL1OwzAYRT2AaCk8AAvKhMSQ8NmfnTgjqlpAqkQHmC3HP1Wi_BEnA29PqkZiusu9R1eHkAcKCQWavlRJ7UPCADCBPAGkV2QNwHiMDMSK3IZQAYAQGd6QFeUpZIzTNXneHVmkWxvtjjzqhy6Muu1KGw3OuH7shiiUp1bXZXu6I9de18HdL7kh3_vd1_Y9Pny-fWxfD7FheTbGkiFi4dAI46kGU-ReZwIcF9pZKbkxHiTXTGoDhZBoHVIhkBlmCwAucUOeLtz5zc_kwqiaMhhX17p13RRURlFwmqZzkV6KZr4dBudVP5SNHn4VBXV2oio1O1FnJwpyNTuZN48LfCoaZ_8XixD8A1qfXhI</recordid><startdate>20031205</startdate><enddate>20031205</enddate><creator>Regan, John W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031205</creationdate><title>EP2 and EP4 prostanoid receptor signaling</title><author>Regan, John W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c297t-82333be3c5cf1a0cb9fa750e45aed884ccf084a28ac0b583de315532c2db00483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>Receptors, Prostaglandin E - physiology</topic><topic>Receptors, Prostaglandin E, EP2 Subtype</topic><topic>Receptors, Prostaglandin E, EP4 Subtype</topic><topic>Second Messenger Systems - genetics</topic><topic>Second Messenger Systems - physiology</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regan, John W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regan, John W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EP2 and EP4 prostanoid receptor signaling</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2003-12-05</date><risdate>2003</risdate><volume>74</volume><issue>2-3</issue><spage>143</spage><epage>153</epage><pages>143-153</pages><issn>0024-3205</issn><abstract>The EP(2) and EP(4) prostanoid receptors are two of the four subtypes of receptors for prostaglandin E(2) (PGE(2)). 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| ispartof | Life sciences (1973), 2003-12, Vol.74 (2-3), p.143-153 |
| issn | 0024-3205 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71354166 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Humans Mice Mice, Knockout Molecular Sequence Data Receptors, Prostaglandin E - physiology Receptors, Prostaglandin E, EP2 Subtype Receptors, Prostaglandin E, EP4 Subtype Second Messenger Systems - genetics Second Messenger Systems - physiology Signal Transduction - genetics Signal Transduction - physiology |
| title | EP2 and EP4 prostanoid receptor signaling |
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