Ipso-Substitution by Cytochrome P450 with Conversion of p-Hydroxybenzene Derivatives to Hydroquinone: Evidence for Hydroperoxo-Iron As the Active Oxygen Species

Evidence for multiple functional active oxidants in cytochrome P450-catalyzed reactions was previously obtained in this laboratory with mutants in which proton delivery was perturbed by replacement of the highly conserved threonine residue in the active site by alanine, thus apparently interfering w...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2002-01, Vol.397 (1), p.119-129
Hauptverfasser:	Vatsis, Kostas P., Coon, Minor J.
Format:	Artikel
Sprache:	eng
Schlagworte:	activated oxygen species Anti-Infective Agents, Local - chemistry Anti-Infective Agents, Local - metabolism Catalysis Cloning, Molecular Cytochrome P-450 Enzyme System - chemistry cytochrome P450 Escherichia coli - enzymology Hydrogen Peroxide - chemistry Hydrogen-Ion Concentration ipso-substitution Iron - chemistry Kinetics Models, Chemical NADP - metabolism Oxygen - metabolism Phenol - chemistry Phenol - metabolism Protein Binding Reactive Oxygen Species Time Factors
Online-Zugang:	Volltext
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