Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells

Ephrin A1 (EFNA1) is a GPI-anchored ligand that preferentially binds to the receptor tyrosine kinase, EphA2. EphA2 is over-expressed in malignant melanocytes and in prostate carcinoma cells. Whether activation of EphA2 by EFNA1 is involved in aberrant growth or differentiation of cancer cells is cur...

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Veröffentlicht in:	Cancer letters 2002-01, Vol.175 (2), p.187-195
Hauptverfasser:	Potla, Lyka, Boghaert, Erwin R, Armellino, Douglas, Frost, Philip, Damle, Nitin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Base Sequence beta Catenin Biological and medical sciences Carcinoma Cell adhesion & migration Cell Division - drug effects Cell Division - physiology Cell growth Chemotherapy Colon cancer Contact inhibition Cytomegalovirus Cytoskeletal Proteins - metabolism DNA Primers E-cadherin EFNA1 EphA2 Ephrin-A1 Ephrin-A2 Experiments Glycosylphosphatidylinositols - metabolism HT29 Cells Humans Hypotheses Kinases Kinetics Ligands Medical sciences Molecular Sequence Data Oligodeoxyribonucleotides, Antisense - pharmacology Pharmacology. Drug treatments Phosphorylation Phosphotyrosine - metabolism Polymerase Chain Reaction Proteins Proteins - genetics Time Factors Trans-Activators Transcription Factors - metabolism Transfection Tumors β-Catenin
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