Risk factors for Barrett's esophagus: A case‐control study
Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 in 8 Ital...
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| Veröffentlicht in: | International journal of cancer 2002-01, Vol.97 (2), p.225-229 |
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| creator | Conio, Massimo Filiberti, Rosangela Blanchi, Sabrina Ferraris, Roberto Marchi, Santino Ravelli, Paolo Lapertosa, Gabriella Iaquinto, Gaetano Sablich, Renato Gusmaroli, Riccardo Aste, Hugo Giacosa, Attilio |
| description | Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life‐style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non‐neoplastic, non‐gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I–III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio‐economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p |
| doi_str_mv | 10.1002/ijc.1583 |
| format | Article |
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Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life‐style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non‐neoplastic, non‐gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I–III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio‐economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p<0.0001), such as the presence of hiatal hernia (p≤0.001). Ulcer was significantly associated with BE (p=0.001). Among patients with E, the risk was directly related to spirits consumption (p=0.03). Patients with GERD symptoms that lasted more than 13 years were more likely to have BE than E (p=0.01). In conclusion, results from our study point out that long‐standing GERD symptoms, hiatal hernia and possibly alcohol consumption are risk factors in the development of the BE and E. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.1583</identifier><identifier>PMID: 11774268</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Barrett Esophagus - epidemiology ; Barrett's esophagus ; Biological and medical sciences ; Case-Control Studies ; esophagitis ; Esophagoscopy ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; GERD ; GOSPE ; Humans ; Incidence ; Italy ; Italy - epidemiology ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Quality of Life ; Risk Factors ; Surveys and Questionnaires ; Tumors</subject><ispartof>International journal of cancer, 2002-01, Vol.97 (2), p.225-229</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4473-4d0352e3678516f42f197e5b16de00cdfc70d3c104c4a4a27efb257a58ed24f03</citedby><cites>FETCH-LOGICAL-c4473-4d0352e3678516f42f197e5b16de00cdfc70d3c104c4a4a27efb257a58ed24f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.1583$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.1583$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13441698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11774268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conio, Massimo</creatorcontrib><creatorcontrib>Filiberti, Rosangela</creatorcontrib><creatorcontrib>Blanchi, Sabrina</creatorcontrib><creatorcontrib>Ferraris, Roberto</creatorcontrib><creatorcontrib>Marchi, Santino</creatorcontrib><creatorcontrib>Ravelli, Paolo</creatorcontrib><creatorcontrib>Lapertosa, Gabriella</creatorcontrib><creatorcontrib>Iaquinto, Gaetano</creatorcontrib><creatorcontrib>Sablich, Renato</creatorcontrib><creatorcontrib>Gusmaroli, Riccardo</creatorcontrib><creatorcontrib>Aste, Hugo</creatorcontrib><creatorcontrib>Giacosa, Attilio</creatorcontrib><creatorcontrib>Gruppo Operativo per lo Studio delle Precancerosi Esofagee (GOSPE)</creatorcontrib><creatorcontrib>GOSPE</creatorcontrib><title>Risk factors for Barrett's esophagus: A case‐control study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life‐style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non‐neoplastic, non‐gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I–III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio‐economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p<0.0001), such as the presence of hiatal hernia (p≤0.001). Ulcer was significantly associated with BE (p=0.001). Among patients with E, the risk was directly related to spirits consumption (p=0.03). Patients with GERD symptoms that lasted more than 13 years were more likely to have BE than E (p=0.01). In conclusion, results from our study point out that long‐standing GERD symptoms, hiatal hernia and possibly alcohol consumption are risk factors in the development of the BE and E. © 2002 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Barrett Esophagus - epidemiology</subject><subject>Barrett's esophagus</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>esophagitis</subject><subject>Esophagoscopy</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>GERD</subject><subject>GOSPE</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Quality of Life</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKw0AUBuBBFFur4BNINl42qXPmkknFTS1eKQii62E6mdHUtKlzEqQ7H8Fn9ElMbaArV2dxPv7D-Qk5BNoHStl5PrV9kCnfIl2gAxVTBnKbdJsVjRXwpEP2EKeUAkgqdkkHQCnBkrRLLp9yfI-8sVUZMPJliK5MCK6qTjFyWC7ezGuNF9Ewsgbdz9e3LedVKIsIqzpb7pMdbwp0B-3skZeb6-fRXTx-vL0fDcexFULxWGSUS-Z4olIJiRfMw0A5OYEkc5TazFtFM26BCiuMMEw5P2FSGZm6jAlPeY-crHMXofyoHVZ6lqN1RWHmrqxRNy9KUIw38GwNbSgRg_N6EfKZCUsNVK-a0k1TetVUQ4_azHoyc9kGttU04LgFBq0pfDBzm-PGcSEgGaxcvHafeeGW_x7U9w-jv8O_GlV-NA</recordid><startdate>20020110</startdate><enddate>20020110</enddate><creator>Conio, Massimo</creator><creator>Filiberti, Rosangela</creator><creator>Blanchi, Sabrina</creator><creator>Ferraris, Roberto</creator><creator>Marchi, Santino</creator><creator>Ravelli, Paolo</creator><creator>Lapertosa, Gabriella</creator><creator>Iaquinto, Gaetano</creator><creator>Sablich, Renato</creator><creator>Gusmaroli, Riccardo</creator><creator>Aste, Hugo</creator><creator>Giacosa, Attilio</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020110</creationdate><title>Risk factors for Barrett's esophagus: A case‐control study</title><author>Conio, Massimo ; Filiberti, Rosangela ; Blanchi, Sabrina ; Ferraris, Roberto ; Marchi, Santino ; Ravelli, Paolo ; Lapertosa, Gabriella ; Iaquinto, Gaetano ; Sablich, Renato ; Gusmaroli, Riccardo ; Aste, Hugo ; Giacosa, Attilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4473-4d0352e3678516f42f197e5b16de00cdfc70d3c104c4a4a27efb257a58ed24f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Barrett Esophagus - epidemiology</topic><topic>Barrett's esophagus</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>esophagitis</topic><topic>Esophagoscopy</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. 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Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case‐control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life‐style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non‐neoplastic, non‐gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I–III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio‐economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p<0.0001), such as the presence of hiatal hernia (p≤0.001). Ulcer was significantly associated with BE (p=0.001). Among patients with E, the risk was directly related to spirits consumption (p=0.03). Patients with GERD symptoms that lasted more than 13 years were more likely to have BE than E (p=0.01). In conclusion, results from our study point out that long‐standing GERD symptoms, hiatal hernia and possibly alcohol consumption are risk factors in the development of the BE and E. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11774268</pmid><doi>10.1002/ijc.1583</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Barrett Esophagus - epidemiology Barrett's esophagus Biological and medical sciences Case-Control Studies esophagitis Esophagoscopy Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen GERD GOSPE Humans Incidence Italy Italy - epidemiology Male Medical sciences Middle Aged Odds Ratio Quality of Life Risk Factors Surveys and Questionnaires Tumors |
| title | Risk factors for Barrett's esophagus: A case‐control study |
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