Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats

About 20–30% of patients with epilepsy continue to have seizures despite carefully monitored treatment with antiepileptic drugs. The mechanisms explaining why some patients' respond and others prove resistant to antiepileptic drugs are poorly understood. It has been proposed that pharmacoresist...

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Veröffentlicht in:	Neuropharmacology 2002, Vol.42 (1), p.107-116
Hauptverfasser:	Jeub, M., Beck, H., Siep, E., Rüschenschmidt, C., Speckmann, E.-J., Ebert, U., Potschka, H., Freichel, C., Reissmüller, E., Löscher, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Antiepileptic drugs Biological and medical sciences Calcium Channels - drug effects Calcium Channels - metabolism Drug Resistance Electrodes, Implanted Electrophysiology Epilepsy Female Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Ion channels Kindling Kindling, Neurologic - physiology Medical sciences Neurons - drug effects Neurons - metabolism Neuropharmacology Patch-Clamp Techniques Pharmacology. Drug treatments Pharmacoresistance Phenytoin - pharmacology Rats Rats, Wistar Sodium Channels - drug effects Sodium Channels - metabolism
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