Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway

Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development and migration, neurite outgrowth, and synaptic transmission. In this study we investigated the relationship between cdk5 activity and regulati...

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Veröffentlicht in:	The Journal of biological chemistry 2002-01, Vol.277 (1), p.528-534
Hauptverfasser:	Sharma, Pushkar, Veeranna, Sharma, Monica, Amin, Niranjana D., Sihag, Ram K., Grant, Philip, Ahn, Natalie, Kulkarni, Ashok B., Pant, Harish C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Cortex - metabolism Down-Regulation MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase Kinases - metabolism Nerve Tissue Proteins - physiology PC12 Cells Phosphorylation Protein-Serine-Threonine Kinases - metabolism Rats Threonine - metabolism
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