Decreased IL-15 May Contribute to Elevated IgE and Acute Inflammation in Atopic Dermatitis

PBMC and acute skin lesions of patients with atopic dermatitis (AD) are characterized by increased IL-4 and IL-13, but decreased IFN-gamma production. This bias toward an increased Th2 cytokine profile may contribute to the elevated IgE levels and acute skin inflammation seen in AD. In this study, w...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-01, Vol.168 (1), p.505-510
Hauptverfasser:	Ong, Peck Y, Hamid, Qutayba A, Travers, Jeffrey B, Strickland, Ian, Kerithy, Muhamed Al, Boguniewicz, Mark, Leung, Donald Y. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Cells, Cultured Chronic Disease Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Flow Cytometry Humans Immunoglobulin E - biosynthesis Interferon-gamma - biosynthesis Interleukin-15 - genetics Interleukin-15 - metabolism Interleukin-15 - physiology Leukocytes, Mononuclear - immunology Monocytes - immunology Psoriasis - immunology Psoriasis - pathology RNA, Messenger - biosynthesis Skin - immunology Skin - pathology
Online-Zugang:	Volltext
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