Efficacy of DNA–hsp65 vaccination for tuberculosis varies with method of DNA introduction in vivo

A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium tuberculosis in a prophylactic setting and also therapeutically reduce the number of bacteria in infected mice. The protective mechanism is thought to be related to Th1-mediated events that result in bacterial k...

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Veröffentlicht in:	Vaccine 2003-12, Vol.22 (1), p.49-56
Hauptverfasser:	Lima, K.M, dos Santos, S.A, Santos, R.R, Brandão, I.T, Rodrigues, J.M, Silva, C.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - analysis Antibodies, Bacterial - biosynthesis Applied microbiology Bacteria Bacterial diseases Bacterial Proteins - immunology Biolistics Biological and medical sciences Chaperonin 60 Chaperonins - immunology Cloning Cytokines Cytokines - biosynthesis Cytotoxicity Deoxyribonucleic acid DNA DNA vaccine DNA, Bacterial - biosynthesis DNA, Bacterial - genetics DNA, Bacterial - immunology Female Fundamental and applied biological sciences. Psychology Gold hsp65 Hsp65 protein Human bacterial diseases Immune response Immune system Immunization Immunogenicity Infections Infectious diseases Injections, Intramuscular Leprosy Lymphocytes Medical sciences Methods Mice Mice, Inbred BALB C Microbiology Microspheres Mycobacterium tuberculosis Plasmids Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis Vaccines - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology
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