Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

Hepatocyte nuclear factor 1 alpha (HNF1α) is a liver enriched homeodomain-containing transcription factor that has been shown to transactivate the promoters of several cytochrome P450 (CYP) genes, including CYP2E1, CYP1A2, CYP7A1, and CYP27, in vitro. In humans, mutations in HNF1α are linked to the...

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Veröffentlicht in:	Biochemical pharmacology 2003-11, Vol.66 (10), p.2011-2020
Hauptverfasser:	Cheung, Connie, Akiyama, Taro E., Kudo, Gen, Gonzalez, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Biological and medical sciences Cholesterol - metabolism Cytochrome P-450 CYP4A - biosynthesis Cytochrome P-450 CYP4A - genetics Cytochrome P-450 CYP4A - metabolism Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 DNA-Binding Proteins Gene Expression Hepatic Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta In Vitro Techniques Liver - metabolism Medical sciences Mice Mice, Transgenic Nuclear Proteins Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Polymerase Chain Reaction - methods Regulation Time Factors Transcription factor Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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