Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia
OBJECTIVE: The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus. METHOD: Right-hemisphere thalami obtained at autopsy from 14 schizophrenic and eight comparison subjects were examined. Computer-assiste...
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| Veröffentlicht in: | The American journal of psychiatry 2002-01, Vol.159 (1), p.59-65 |
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| creator | Byne, William Buchsbaum, Monte S. Mattiace, Linda A. Hazlett, Erin A. Kemether, Eileen Elhakem, Sharif L. Purohit, Dushyant P. Haroutunian, Vahram Jones, Liesl |
| description | OBJECTIVE: The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus. METHOD: Right-hemisphere thalami obtained at autopsy from 14 schizophrenic and eight comparison subjects were examined. Computer-assisted morphometric techniques were used to determine volumes for the mediodorsal nucleus, pulvinar, and the anterior and centromedian nuclei as well as the parvocellular, magnocellular, and caudodorsal subdivisions of the mediodorsal nucleus. Neurons in the mediodorsal nucleus and pulvinar were counted and measured by using a stereology-based sampling strategy. RESULTS: Four schizophrenic and three comparison subjects had Alzheimer's type pathology, leaving 10 schizophrenic and five comparison subjects without other documented neuropathological changes. In analyses that included either the full cohort or only the subjects without Alzheimer's type pathology, volumes of the mediodorsal nucleus and pulvinar, but not the anterior or centromedian nuclei, were significantly smaller in the schizophrenic subjects. For the schizophrenic subjects, neuronal number in the mediodorsal nucleus, parvocellular subdivision, and pulvinar was significantly lower, and neuronal size in the mediodorsal nucleus, caudodorsal subdivision, and pulvinar was significantly smaller. CONCLUSIONS: Schizophrenia is associated with volume and neuronal changes in the mediodorsal nucleus and pulvinar, the major association nuclei of the thalamus, whereas total thalamic volume and the volumes of anterior and centromedian nuclei were not significantly altered. |
| doi_str_mv | 10.1176/appi.ajp.159.1.59 |
| format | Article |
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METHOD: Right-hemisphere thalami obtained at autopsy from 14 schizophrenic and eight comparison subjects were examined. Computer-assisted morphometric techniques were used to determine volumes for the mediodorsal nucleus, pulvinar, and the anterior and centromedian nuclei as well as the parvocellular, magnocellular, and caudodorsal subdivisions of the mediodorsal nucleus. Neurons in the mediodorsal nucleus and pulvinar were counted and measured by using a stereology-based sampling strategy. RESULTS: Four schizophrenic and three comparison subjects had Alzheimer's type pathology, leaving 10 schizophrenic and five comparison subjects without other documented neuropathological changes. In analyses that included either the full cohort or only the subjects without Alzheimer's type pathology, volumes of the mediodorsal nucleus and pulvinar, but not the anterior or centromedian nuclei, were significantly smaller in the schizophrenic subjects. For the schizophrenic subjects, neuronal number in the mediodorsal nucleus, parvocellular subdivision, and pulvinar was significantly lower, and neuronal size in the mediodorsal nucleus, caudodorsal subdivision, and pulvinar was significantly smaller. CONCLUSIONS: Schizophrenia is associated with volume and neuronal changes in the mediodorsal nucleus and pulvinar, the major association nuclei of the thalamus, whereas total thalamic volume and the volumes of anterior and centromedian nuclei were not significantly altered.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.159.1.59</identifier><identifier>PMID: 11772691</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Anterior Thalamic Nuclei - pathology ; Biological and medical sciences ; Comparative studies ; Female ; Geriatrics ; Humans ; Image Processing, Computer-Assisted ; Intralaminar Thalamic Nuclei - pathology ; Male ; Medical sciences ; Mediodorsal Thalamic Nucleus - pathology ; Middle Aged ; Neurology ; Neurons - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Pulvinar - pathology ; Reference Values ; Schizophrenia ; Schizophrenia - pathology ; Thalamic Nuclei - pathology</subject><ispartof>The American journal of psychiatry, 2002-01, Vol.159 (1), p.59-65</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a393t-ad0e09ba4dbc8e6b687cf31c1cf6dc799681771ad9f7d7bed0f064c2f60f82df3</citedby><cites>FETCH-LOGICAL-a393t-ad0e09ba4dbc8e6b687cf31c1cf6dc799681771ad9f7d7bed0f064c2f60f82df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.159.1.59$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.159.1.59$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2854,4023,21625,21626,21627,27922,27923,27924,77665,77670</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13430663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11772691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byne, William</creatorcontrib><creatorcontrib>Buchsbaum, Monte S.</creatorcontrib><creatorcontrib>Mattiace, Linda A.</creatorcontrib><creatorcontrib>Hazlett, Erin A.</creatorcontrib><creatorcontrib>Kemether, Eileen</creatorcontrib><creatorcontrib>Elhakem, Sharif L.</creatorcontrib><creatorcontrib>Purohit, Dushyant P.</creatorcontrib><creatorcontrib>Haroutunian, Vahram</creatorcontrib><creatorcontrib>Jones, Liesl</creatorcontrib><title>Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus. METHOD: Right-hemisphere thalami obtained at autopsy from 14 schizophrenic and eight comparison subjects were examined. Computer-assisted morphometric techniques were used to determine volumes for the mediodorsal nucleus, pulvinar, and the anterior and centromedian nuclei as well as the parvocellular, magnocellular, and caudodorsal subdivisions of the mediodorsal nucleus. Neurons in the mediodorsal nucleus and pulvinar were counted and measured by using a stereology-based sampling strategy. RESULTS: Four schizophrenic and three comparison subjects had Alzheimer's type pathology, leaving 10 schizophrenic and five comparison subjects without other documented neuropathological changes. In analyses that included either the full cohort or only the subjects without Alzheimer's type pathology, volumes of the mediodorsal nucleus and pulvinar, but not the anterior or centromedian nuclei, were significantly smaller in the schizophrenic subjects. For the schizophrenic subjects, neuronal number in the mediodorsal nucleus, parvocellular subdivision, and pulvinar was significantly lower, and neuronal size in the mediodorsal nucleus, caudodorsal subdivision, and pulvinar was significantly smaller. CONCLUSIONS: Schizophrenia is associated with volume and neuronal changes in the mediodorsal nucleus and pulvinar, the major association nuclei of the thalamus, whereas total thalamic volume and the volumes of anterior and centromedian nuclei were not significantly altered.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - pathology</subject><subject>Anterior Thalamic Nuclei - pathology</subject><subject>Biological and medical sciences</subject><subject>Comparative studies</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Intralaminar Thalamic Nuclei - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mediodorsal Thalamic Nucleus - pathology</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Pulvinar - pathology</subject><subject>Reference Values</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Thalamic Nuclei - pathology</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpaTZpf0AvRRSamx192JJ1DKFtAqEJJG1yE7IssVpsy9XYh-TXR9tdEgjkNAw878zLg9AXSkpKpTgx0xRKs5lKWquSlrV6h1a05nUhGWveoxUhhBWq5vcH6BBgk1fCJfuIDnJaMqHoCl1fR5iHmGY34FMABzC4ccbR49u16c0QLP692N6ZhP_Gfhkc4DDim6XdODsDvgvzGt_YdXiM0zq5MZhP6IM3PbjP-3mE_vz8cXt2Xlxe_bo4O70sDFd8LkxHHFGtqbrWNk60opHWc2qp9aKzUinR5I7UdMrLTrauI56IyjIviG9Y5_kROt7dnVL8tziY9RDAur43o4sLaEl51TREZfDbK3ATlzTmbpoxUjWUyy1Ed5BNESA5r6cUBpMeNCV661pvXevsWmfXmup6m_m6P7y0g-teEnu5Gfi-BwxY0_tkRhvgheMVJ0LwzJU77v-P53Zvf34CpgKZrQ</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Byne, William</creator><creator>Buchsbaum, Monte S.</creator><creator>Mattiace, Linda A.</creator><creator>Hazlett, Erin A.</creator><creator>Kemether, Eileen</creator><creator>Elhakem, Sharif L.</creator><creator>Purohit, Dushyant P.</creator><creator>Haroutunian, Vahram</creator><creator>Jones, Liesl</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia</title><author>Byne, William ; Buchsbaum, Monte S. ; Mattiace, Linda A. ; Hazlett, Erin A. ; Kemether, Eileen ; Elhakem, Sharif L. ; Purohit, Dushyant P. ; Haroutunian, Vahram ; Jones, Liesl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a393t-ad0e09ba4dbc8e6b687cf31c1cf6dc799681771ad9f7d7bed0f064c2f60f82df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - pathology</topic><topic>Anterior Thalamic Nuclei - pathology</topic><topic>Biological and medical sciences</topic><topic>Comparative studies</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Intralaminar Thalamic Nuclei - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mediodorsal Thalamic Nucleus - pathology</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Pulvinar - pathology</topic><topic>Reference Values</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Thalamic Nuclei - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Byne, William</creatorcontrib><creatorcontrib>Buchsbaum, Monte S.</creatorcontrib><creatorcontrib>Mattiace, Linda A.</creatorcontrib><creatorcontrib>Hazlett, Erin A.</creatorcontrib><creatorcontrib>Kemether, Eileen</creatorcontrib><creatorcontrib>Elhakem, Sharif L.</creatorcontrib><creatorcontrib>Purohit, Dushyant P.</creatorcontrib><creatorcontrib>Haroutunian, Vahram</creatorcontrib><creatorcontrib>Jones, Liesl</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Byne, William</au><au>Buchsbaum, Monte S.</au><au>Mattiace, Linda A.</au><au>Hazlett, Erin A.</au><au>Kemether, Eileen</au><au>Elhakem, Sharif L.</au><au>Purohit, Dushyant P.</au><au>Haroutunian, Vahram</au><au>Jones, Liesl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>159</volume><issue>1</issue><spage>59</spage><epage>65</epage><pages>59-65</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus. METHOD: Right-hemisphere thalami obtained at autopsy from 14 schizophrenic and eight comparison subjects were examined. Computer-assisted morphometric techniques were used to determine volumes for the mediodorsal nucleus, pulvinar, and the anterior and centromedian nuclei as well as the parvocellular, magnocellular, and caudodorsal subdivisions of the mediodorsal nucleus. Neurons in the mediodorsal nucleus and pulvinar were counted and measured by using a stereology-based sampling strategy. RESULTS: Four schizophrenic and three comparison subjects had Alzheimer's type pathology, leaving 10 schizophrenic and five comparison subjects without other documented neuropathological changes. In analyses that included either the full cohort or only the subjects without Alzheimer's type pathology, volumes of the mediodorsal nucleus and pulvinar, but not the anterior or centromedian nuclei, were significantly smaller in the schizophrenic subjects. For the schizophrenic subjects, neuronal number in the mediodorsal nucleus, parvocellular subdivision, and pulvinar was significantly lower, and neuronal size in the mediodorsal nucleus, caudodorsal subdivision, and pulvinar was significantly smaller. CONCLUSIONS: Schizophrenia is associated with volume and neuronal changes in the mediodorsal nucleus and pulvinar, the major association nuclei of the thalamus, whereas total thalamic volume and the volumes of anterior and centromedian nuclei were not significantly altered.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>11772691</pmid><doi>10.1176/appi.ajp.159.1.59</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - pathology Anterior Thalamic Nuclei - pathology Biological and medical sciences Comparative studies Female Geriatrics Humans Image Processing, Computer-Assisted Intralaminar Thalamic Nuclei - pathology Male Medical sciences Mediodorsal Thalamic Nucleus - pathology Middle Aged Neurology Neurons - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Pulvinar - pathology Reference Values Schizophrenia Schizophrenia - pathology Thalamic Nuclei - pathology |
| title | Postmortem Assessment of Thalamic Nuclear Volumes in Subjects With Schizophrenia |
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